ArticleNPJ Parkinson's disease2022
Axial impairment and falls in Parkinson's disease: 15 years of subthalamic deep brain stimulation.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Non-motor symptoms burden and motor recovery following STN-DBS in Parkinson's disease: a data-driven longitudinal analysis.Journal of neurology · 2026Article
- Frequency- and Network-Specific Changes in Functional Connectivity Reflect Pathophysiological Mechanisms across Parkinson's Disease Stages.Annals of neurology · 2026Article
- Towards the Prevention of Freezing of Gait in Parkinson's Disease.The European journal of neuroscience · 2026Review
- What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Using explainable AI to identify disease-relevant and deep brain stimulation treatment-sensitive gait features in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Clinical Utility ofGenes · 2026Review
- Consensus expert recommendations for referral of Parkinson's disease patients for deep brain stimulation surgery.NPJ Parkinson's disease · 2026Review
- Development and Validation of a Machine Learning Model for Predicting Osteoporosis in Patients with Parkinson's Disease.Neuropsychiatric disease and treatment · 2026Article
- Differential Effects of Levodopa and Stimulation on Post-Surgery Freezing of Gait in Subthalamic Nucleus Deep Brain Stimulation Parkinson's Disease Patients: A Clinical and Kinematic Analysis.Movement disorders clinical practice · 2025Article
- Unraveling the role of GBA1 genotype in axial signs response to subthalamic deep brain stimulation.NPJ Parkinson's disease · 2025Article
- Sleep stage mixing is associated with poor prognosis in early Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Patient, target, device, and program selection for DBS in Parkinson's disease: advancing toward precision care.NPJ Parkinson's disease · 2025Review
- Ventral STN stimulation is associated with improved axial motor outcomes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Management of freezing of gait - mechanism-based practical recommendations.Nature reviews. Neurology · 2025Review
- Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- The Effects of Deep Brain Stimulation on Balance in Parkinson's Disease as Measured Using Posturography-A Narrative Review.Brain sciences · 2025Review
- Abnormal arm swing movements in Parkinson's disease: onset, progression and response to L-Dopa.Journal of neuroengineering and rehabilitation · 2025Article
- Nonmotor Symptom Changes and Their Association With Falls Among Parkinson's Disease Patients Undergoing Deep Brain Stimulation: A 1-Year Cohort Study.CNS neuroscience & therapeutics · 2025Article
- Detailed investigation of the levodopa response rates in distinct motor subscores in Parkinson's disease patients with and without STN-DBS.Neurodegenerative disease management · 2025Article
- Cerebral Amyloid-β Deposition, Axial Features, and Cognitive Alterations in Patients with Parkinson's Disease Treated with Bilateral STN-DBS: A Long-Term Cohort Study.Journal of personalized medicine · 2024Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this retrospective study, we longitudinally analyzed axial impairment and falls in people with Parkinson's disease (PD) and subthalamic nucleus deep brain stimulation (STN-DBS). Axial scores and falling frequency were examined at baseline, and 1, 10, and 15 years after surgery. Preoperative demographic and clinical data, including PD duration and severity, phenotype, motor and cognitive scales, medications, and vascular changes on neuroimaging were examined as possible risk factors through Kaplan-Meier and Cox regression analyses. Of 302 individuals examined before and at 1 year after surgery, 102 and 57 were available also at 10 and 15 years of follow-up, respectively. Axial scores were similar at baseline and at 1 year but worsened at 10 and 15 years. The prevalence rate of frequent fallers progressively increased from baseline to 15 years. Preoperative axial scores, frontal dysfunction and age at PD onset were risk factors for axial impairment progression after surgery. Axial scores, akinetic/rigid phenotype, age at disease onset and disease duration at surgery predicted frequent falls. Overall, axial signs progressively worsened over the long-term period following STN-DBS, likely related to the progression of PD, especially in a subgroup of subjects with specific risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.