Evidence map›Paper›PMID 36153304›Full record

ArticleHipertension y riesgo vascular

Carotid intima media thickness (CIMT) in adults in the AWI-Gen Nairobi site study: Profiles and predictors.

S F Mohamed, C Khayeka-Wandabwa, S Muthuri, N N Ngomi, C Kyobutungi, T N Haregu

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In one paragraph

Article in Hipertension y riesgo vascular. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

S F MohamedHealth and Systems for Health Unit, African Population and Health Research Center (APHRC), Nairobi, Kenya; Lown Scholars Program, Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA; School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin 300072, China. Electronic address: smohamed@aphrc.org.
C Khayeka-WandabwaSchool of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin 300072, China.
S MuthuriHealth and Systems for Health Unit, African Population and Health Research Center (APHRC), Nairobi, Kenya.
N N NgomiSchool of Pure and Applied Health Science, Murang'a University of Technology, Thika, Kenya.
C KyobutungiHealth and Systems for Health Unit, African Population and Health Research Center (APHRC), Nairobi, Kenya.
T N HareguNossal Institute for Global Health, University of Melbourne, Melbourne, Australia.
African Population and Health Research Center · KETianjin University · CNMurang'a University of Technology · KEThe University of Melbourne · AU

Funding

Shared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI RAMSAY, MICHELE MICHELE · 2012 to 2022
$12.2M
NHGRI NIH HHS U54 HG006938
6 · The paper itself

Abstract

backgroundCarotid intima media thickness (CIMT) is used as a marker of subclinical and asymptomatic atherosclerotic vascular disease. Increased CIMT is associated with future cerebrovascular and cardiovascular events. There is limited data on the profile and correlates of CIMT in Africa. The aim of this study was to describe the profile and correlates of CIMT in apparently normal younger-age adults in an urban setting in Kenya.

methodsThis study used population-based data collected from 2003 adults between the ages of 40 and 60 years in two slums of Nairobi as part of a genetic study. CIMT was measured using LOGIQ e (GE Healthcare, CT, USA) ultrasound on both left and right carotid arteries, whereby maximum, mean, and minimum values were recorded. Age- and sex-specific CIMT measurements were calculated and their association with basic sociodemographic, behavioral and body composition indicators were investigated.

resultsThe median (IQR) CIMT were 0.58 (0.51, 0.66) and 0.59 (0.53, 0.66) in men and women, respectively. About 16% of the study population had CIMT greater than 0.7mm, the cut off for higher CIMT. Nearly 60% had CIMT values ≥75th percentile. Age, current use of alcohol, systolic blood pressure, subcutaneous fat thickness, pulse rate and pulse pressure were found to be the main predictors of CIMT in our study population.

conclusionThis study provided population-based reference values and predictors for CIMT for an adult population living in urban poor settings in Kenya. Future studies need to consider biochemical and genetic predictors of CIMT in this population.

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessAdultBlood PressureCarotid ArteriesFemaleHumansKenyaMaleMiddle AgedRisk FactorsCarotid intima media thickness (CIMT)Grosor de la grasa subcutáneaGrosor de la íntima-media carotídeaPoblación urbana con pocos recursosPresión arterial sistólicaPresión del pulsoPulse pressureSubcutaneous fat thicknessSystolic blood pressureUrban poor

Identifiers

PMID36153304
PMCPMC11317065
OpenAlexW4296620571

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.