Evidence map›Paper›PMID 36153270›Full record

ArticleAmerican journal of surgery2022

Fibrinolysis resistance after liver transplant as a predictor of early infection.

Ivan E Rodriguez, Dor Yoeli, Tanner Ferrell, Jessie G Jiang, Ronald Truong, Trevor L Nydam, Megan A Adams, J Michael Cullen, Elizabeth A Pomfret, Hunter B Moore

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Characteristics of Gram-positive cocci infection and the therapeutic effect after liver transplantation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ivan E RodriguezColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA. Electronic address: ivan.2.rodriguez@cuanschutz.edu.
Dor YoeliColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.
Tanner FerrellColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.
Jessie G JiangUniversity of Colorado School of Medicine, CU Anschutz Fitzsimons Building, 13001 East 17th Place, C290, Aurora, CO, 80045, USA.
Ronald TruongUniversity of Colorado School of Medicine, CU Anschutz Fitzsimons Building, 13001 East 17th Place, C290, Aurora, CO, 80045, USA.
Trevor L NydamColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.
Megan A AdamsDepartment of Surgery, Division of Transplant Surgery, Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO, 80045, USA.
J Michael CullenColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.
Elizabeth A PomfretColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.
Hunter B MooreColorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

Fibrinolysis Dysfunction Impact on Graft Function in Liver TransplantationR00HL151887 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOORE, HUNTER B · 2021 to 2023
$747k
NHLBI NIH HHS R00 HL151887
6 · The paper itself

Abstract

backgroundInfection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection.

methodsFibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR. FR was defined as LY30 = 0% and stratified as transient if present on POD1 or POD5 (tFR), persistent (pFR) if present on both, or no FR (nFR) if absent.

results180 LT recipients were prospectively enrolled. 52 (29%) recipients developed infection. 72 had tFR; 37 had pFR; and 71 had nFR. Recipients with pFR had significantly greater incidence of infections (51% vs. 26% tFR vs. 20% nFR, p = 0.002). pFR was independently associated with increased odds of post-transplant infection (adjusted OR 3.39, p = 0.009).

conclusionsPersistent fibrinolysis resistance is associated with increased risk of post-transplant infection.

Indexed as

FibrinolysisLiver TransplantationSurgical Wound InfectionHumansPlasminogen Activator Inhibitor 1SepsisThrombelastographyTissue Plasminogen ActivatorPlasminogen Activator Inhibitor 1Tissue Plasminogen ActivatorFibrinolysis resistanceInfectionLiver transplantPlasminogen activator inhibitor 1 (PAI-1)Thrombelastography (TEG)

Identifiers

PMID36153270
PMCPMC10424327
OpenAlexW4296901305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.