Evidence map›Paper›PMID 36153024›Full record

ArticleBMJ open2022

Characterising persons diagnosed with HIV as either recent or long-term using a cross-sectional analysis of recent infection surveillance data collected in Malawi from September 2019 to March 2020.

Malango T Msukwa, Ellen W MacLachlan, Salem T Gugsa, Joe Theu, Ireen Namakhoma, Fred Bangara, Christopher L Blair, Danielle Payne, Kathryn G Curran, Melissa Arons and 11 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 2 countries.

Malango T MsukwaDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
Ellen W MacLachlanDepartment of Global Health, I-TECH, University of Washington, Seattle, Washington, USA emaclach@uw.edu.ORCID 0000-0003-4106-8290
Salem T GugsaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Joe TheuDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
Ireen NamakhomaDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
Fred BangaraDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
Christopher L BlairDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
Danielle PayneCenters for Disease Control and Prevention, Lilongwe, Malawi.
Kathryn G CurranCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Melissa AronsCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Khumbo NamachapaDepartment of HIV and AIDS, Ministry of Health, Lilongwe, Central Region, Malawi.
Nellie WadondaCenters for Disease Control and Prevention, Lilongwe, Malawi.
Alinune N KabagheCenters for Disease Control and Prevention, Lilongwe, Malawi.
Trudy DobbsCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Vedapuri ShanmugamCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Evelyn KimCenters for Disease Control and Prevention, Lilongwe, Malawi.
Andrew AuldCenters for Disease Control and Prevention, Lilongwe, Malawi.
Yusuf BabayeDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
Gabrielle O'MalleyDepartment of Global Health, I-TECH, University of Washington, Seattle, Washington, USA.
Rose NyirendaDepartment of HIV and AIDS, Ministry of Health, Lilongwe, Central Region, Malawi.
George BelloDepartment of Global Health, I-TECH, University of Washington, Lilongwe, Malawi.
University of Washington · USCenters for Disease Control and Prevention · USMinistry of Health · MW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn Malawi, a recent infection testing algorithm (RITA) is used to characterise infections of persons newly diagnosed with HIV as recent or long term. This paper shares results from recent HIV infection surveillance and describes distribution and predictors.

settingData from 155 health facilities in 11 districts in Malawi were pooled from September 2019 to March 2020.

participantsEligible participants were ≥13 years, and newly diagnosed with HIV. Clients had RITA recent infections if the rapid test for recent infection (RTRI) test result was recent and viral load (VL) ≥1000 copies/mL; if VL was <1000 copies/mL the RTRI result was reclassified as long-term. Results were stratified by age, sex, pregnancy/breastfeeding status and district.

results13 838 persons consented to RTRI testing and 12 703 had valid RTRI test results and VL results after excluding clients not newly HIV-positive, RTRI negative or missing data (n=1135). A total of 12 365 of the 12 703 were included in the analysis after excluding those whose RTRI results were reclassified as long term (n=338/784 or 43.1%). The remainder, 446/12 703 or 3.5%, met the definition of RITA recent infection. The highest percentage of recent infections was among breastfeeding women (crude OR (COR) 3.2; 95% CI 2.0 to 5.0), young people aged 15-24 years (COR 1.6; 95% CI 1.3 to 1.9) and persons who reported a negative HIV test within the past 12 months (COR 3.3; 95% CI 2.6 to 4.2). Factors associated with recent infection in multivariable analysis included being a non-pregnant female (adjusted OR (AOR) 1.4; 95% CI 1.2 to 1.8), a breastfeeding female (AOR 2.2; 95% CI 1.4 to 3.5), aged 15-24 years (AOR 1.6; 95% CI 1.3 to 1.9) and residents of Machinga (AOR 2.0; 95% CI 1.2 to 3.5) and Mzimba (AOR 2.4; 95% CI 1.3 to 4.5) districts.

conclusionsMalawi's recent HIV infection surveillance system demonstrated high uptake and identified sub-populations of new HIV diagnoses with a higher percentage of recent infections.

Indexed as

HIV InfectionsPregnancy Complications, InfectiousAdolescentCross-Sectional StudiesFemaleHumansMalawiPregnancyViral LoadEPIDEMIOLOGYHIV & AIDSINFECTIOUS DISEASESPublic health

Identifiers

PMID36153024
PMCPMC9511604
OpenAlexW4297250767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.