Trial reportAlcohol (Fayetteville, N.Y.)2023
Influence of age and sex on alcohol pharmacokinetics and subjective pharmacodynamic responses following intravenous alcohol exposure in humans.
Trial report in Alcohol (Fayetteville, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Effects of acute alcohol consumption on hostile attribution bias towards emotional facial expressions and implicit approach/avoidance tendencies.Journal of psychopharmacology (Oxford, England) · 2026Trial
- Demographic and clinical profiles of drug-induced psychosis: age, gender, and social context in a German cohort.European archives of psychiatry and clinical neuroscience · 2026Article
- Sex differences in alcohol use and perceptions of cognitive health in rural Uganda.BMC geriatrics · 2026Article
- Article
- Moderate Wine Consumption, Defined by the Mediterranean Diet, Is Associated With Delayed Biological Aging in Men From the Moli-sani Study.International journal of public health · 2026Article
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- Glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery.Frontiers in pharmacology · 2025Article
- Knowledge of the consequences of excessive alcohol consumption among emerging adult college students.Revista da Escola de Enfermagem da U S P · 2025Article
- Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males.Frontiers in psychiatry · 2025Article
- Assessing alcohol consumption across phosphatidylethanol levels using HDL-cholesterol as a predictor.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Endpoints for Pharmacotherapy Trials for Alcohol Use Disorder.Pharmaceutical medicine · 2024Review
- Moderate alcohol consumption, types of beverages and drinking pattern with cardiometabolic biomarkers in three cohorts of US men and women.European journal of epidemiology · 2023Article
- Response to commentary on: "Fat-free mass accounts for most of the variance in alcohol elimination rate in women".Alcohol, clinical & experimental research · 2023Article
- Fat-free mass accounts for most of the variance in alcohol elimination rate in women.Alcohol, clinical & experimental research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
There are substantial inter-individual variations in alcohol metabolism and response that are likely due to sex and age; however, these are not well understood. We investigated age and sex influences on alcohol elimination rate (AER) and subjective responses following intravenous (IV) administration in non-dependent drinkers. Participants underwent a 2-session study where they received IV alcohol (target breath alcohol level: 0.05 g%) and placebo in counter-balanced order. AER was higher in males than in females across age groups. These differences were partly explained by sex differences in lean body mass and liver volume. Alcohol significantly increased peak feelings of high, intoxication, drug-effects, liking-effects, and wanting-more, with no major sex differences. There were no age-related differences in feelings of high and intoxication; however, the older group reported significantly lower peak liking-effects and stimulation responses than the younger group. These findings highlight the significant impact of sex and age as sources of variability in the clinical pharmacology of alcohol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.