Evidence map›Paper›PMID 36152631›Full record

ArticleCurrent biology : CB2022

Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.

Carey Y L Huh, Henri Leinonen, Taylor Nakayama, Julia R Tomasello, Jianye Zhang, Jack Zeitoun, John P Peach, Maximilian Halabi, Jianying Z Kiser, Krzysztof Palczewski and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  3. White matter plasticity following cataract surgery in congenitally blind patients.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Carey Y L HuhDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Henri LeinonenGavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Taylor NakayamaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Julia R TomaselloDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Jianye ZhangGavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA.
Jack ZeitounDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
John P PeachWhiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Maximilian HalabiGavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
Jianying Z KiserGavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA.
Krzysztof PalczewskiGavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA; Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Philip D KiserGavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA; Research Service, VA Long Beach Healthcare System, Long Beach, CA 90822, USA; Department of Clinical Pharmacy Practice, University of California, Irvine, Irvine, CA 92697, USA.
Sunil P GandhiDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: spgandhi@uci.edu.
University of California, Irvine · USJohns Hopkins University · USVA Long Beach Healthcare System · US

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
Novel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
Reorganization of the Central Visual System by Inhibitory Neuron TransplantationR01EY029490 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LUR, GYORGY · 2019 to 2023
$2.6M
Retinoid cycles and retinal disease treatmentI01BX004939 · VA · VETERANS HEALTH ADMINISTRATION · PI KISER, PHILIP DAVID · 2020 to 2025
–
BLRD VA I01 BX004939NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY029490NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283
6 · The paper itself

Abstract

Despite the recent emergence of multiple cellular and molecular strategies to restore vision in retinal disorders, it remains unclear to what extent central visual circuits can recover when retinal defects are corrected in adulthood. We addressed this question in an Lrat

Indexed as

Retinal DegenerationAnimalsCalciumcis-trans-IsomerasesEye ProteinsMiceRetinaRetinoidsCalciumcis-trans-IsomerasesEye ProteinsRetinoids9-cis-retinyl acetatebinocularitychildhood blindnessLeber congenital amaurosisLratretinal degenerationretinal diseaseretinoid treatmenttwo-photon calcium imagingV1

Identifiers

PMID36152631
PMCPMC10083103
OpenAlexW4296819825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.