ArticleAmerican journal of human genetics2022
ExPRSweb: An online repository with polygenic risk scores for common health-related exposures.
Article in American journal of human genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks.PLoS genetics · 2023Pooled it
- Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention.Clinical pharmacology and therapeutics · 2026Article
- Predominantly genetic, intrauterine, and lifestyle aetiologies of type 2 diabetes are associated with distinct clinical presentations and risk of complications: a Danish cross-sectional and follow-up study.EClinicalMedicine · 2026Article
- PGS Browser: a public platform for personalized polygenic score analysis and interpretation.Nature communications · 2026Article
- Longitudinal prediction of BMI using explainable AI: integrating polygenic scores, maternal, early-life and familial factors.International journal of obesity (2005) · 2026Observational
- Polygenic Risk Scores Predicting Estimated GFR Validated With Iohexol Clearance.Kidney international reports · 2026Article
- Risk prediction for cardiovascular related diseases using PRS and EHR in the Framingham Heart Study.PloS one · 2026Article
- Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.Genome medicine · 2025Article
- PTL-PRS: an R package for transfer learning of polygenic risk scores with pseudovalidation.Bioinformatics (Oxford, England) · 2025Article
- PGSFusion streamlines polygenic score construction and epidemiological applications in biobank-scale cohorts.Genome medicine · 2025Article
- A Bayesian approach to correcting the attenuation bias of regression using polygenic risk score.Genetics · 2025Article
- Single-Ancestry versus Multi-Ancestry Polygenic Risk Scores for CKD in Black American Populations.Journal of the American Society of Nephrology : JASN · 2024Article
- Reducing Information and Selection Bias in EHR-Linked Biobanks via Genetics-Informed Multiple Imputation and Sample Weighting.medRxiv : the preprint server for health sciences · 2024Article
- Lipid Trajectories Improve Risk Models for Alzheimer's Disease and Mild Cognitive Impairment.medRxiv : the preprint server for health sciences · 2024Article
- Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers.Nucleic acids research · 2024Article
- To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Exploring the genetics of lithium response in bipolar disorders.International journal of bipolar disorders · 2024Article
- To weight or not to weight? Studying the effect of selection bias in three large EHR-linked biobanks.medRxiv : the preprint server for health sciences · 2024Article
- Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction.Communications biology · 2024Article
- Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population.International journal of molecular sciences · 2024Article
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5 authors.
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Abstract
Complex traits are influenced by genetic risk factors, lifestyle, and environmental variables, so-called exposures. Some exposures, e.g., smoking or lipid levels, have common genetic modifiers identified in genome-wide association studies. Because measurements are often unfeasible, exposure polygenic risk scores (ExPRSs) offer an alternative to study the influence of exposures on various phenotypes. Here, we collected publicly available summary statistics for 28 exposures and applied four common PRS methods to generate ExPRSs in two large biobanks: the Michigan Genomics Initiative and the UK Biobank. We established ExPRSs for 27 exposures and demonstrated their applicability in phenome-wide association studies and as predictors for common chronic conditions. Especially the addition of multiple ExPRSs showed, for several chronic conditions, an improvement compared to prediction models that only included traditional, disease-focused PRSs. To facilitate follow-up studies, we share all ExPRS constructs and generated results via an online repository called ExPRSweb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.