ArticleOphthalmology and therapy2022
Efficacy of Autologous Serum Gel in Neurotrophic Persistent Corneal Epithelial Defects Combined with Lagophthalmos.
Article in Ophthalmology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Effects of autologous serum and artificial tears on corneal sensation and tear film stability in patients with mild to moderate xerophthalmia after cataract surgery.International ophthalmology · 2025Trial
- Comparison of Nerve Growth Factor with Fetal Bovine Serum for Promoting Closure of Defects in Corneal Epithelial Cell Layers.Biomedicines · 2026Article
- Corneal nerve regeneration and ocular surface restoration following treatment with autologous serum eye drops in patients with paralytic lagophthalmos and neurotrophic keratitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo investigate the efficacy of autologous serum gel in patients with lagophthalmos combined with neurotrophic persistent corneal epithelial defects (PEDs).
methodsThis is retrospective, case-series study enrolled 15 patients with lagophthalmos complicated by neurotrophic PEDs refractory to medical treatment including autologous serum eye drops. They were treated with autologous serum gel in conjunction with conservative treatment. The following information was collected from medical records: demographics, underlying diseases, and past ocular history. PEDs healing time was evaluated with visual acuity, visual analog scale (VAS) scores, esthesiometer scores, and the areas of the epithelial defects.
resultsSix men and nine women with a mean age of 63.3 ± 9.9 years were included. The most common cause of the neurotrophic PEDs and lagophthalmos in this group was postherpetic infection (46.7%) and cerebral hemorrhage (26.7%) each. Two months following treatment with autologous serum gel, there was a reduction in the area of the epithelial defects (from 19.2 ± 9.9 to 0.6 ± 1.5 mm
conclusionsAutologous serum gel reduces symptoms and promotes corneal epithelialization of refractory neurotrophic PEDs in patients with lagophthalmos. Therefore, it may be well tolerated and a beneficial addition in the management of neurotrophic PEDs in patients with lagophthalmos.
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