Evidence map›Paper›PMID 36152116›Full record

ArticleCardiology and therapy2022

Impact of Cardiovascular Risk Factors on Arterial Stiffness in a Countryside Area of Switzerland: Insights from the Swiss Longitudinal Cohort Study.

Lucrezia Pusterla, Dragana Radovanovic, Franco Muggli, Paul Erne, Andreas W Schoenenberger, Renate Schoenenberger-Berzins, Gianfranco Parati, Paolo Suter, Sebastiano A G Lava, Augusto Gallino and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02282748 (Swiss Longitudinal Cohort), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02282748 recruitingnot on this map

Swiss Longitudinal Cohort

TypeobservationalSponsorHypertension Excellence Centre LucerneRan2014 to 2034Enrolled1,000ConditionsCardiovascular Risk FactorsArmsNo intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Lucrezia PusterlaFamily Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Dragana RadovanovicFamily Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Franco MuggliFamily Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Paul ErneFamily Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Andreas W SchoenenbergerDepartment of Geriatrics, Inselspital, Bern University Hospital, and University of Bern,, Bern, Switzerland.
Renate Schoenenberger-BerzinsHerzzentrum, Kantonsspital, Lucerne, Switzerland.
Gianfranco ParatiIstituto Auxologico Italiano, IRCCS, Cardiology Unit and Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy.
Paolo SuterDepartment of Internal Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Sebastiano A G LavaPediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland. webmaster@sebastianolava.ch.ORCID http://orcid.org/0000-0002-8391-5462
Augusto GallinoCardiovascular Research, San Giovanni Hospital, EOC, Bellinzona, Switzerland.
Mario G BianchettiFamily Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Università della Svizzera italiana · CHGreat Ormond Street Hospital · GBIRCCS Istituto Auxologico Italiano · ITLuzerner Kantonsspital · CHOspedale San Giovanni Bellinzona · CHUniversity of Bern · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCardiovascular disease is the leading cause of morbidity and mortality. Besides traditional cardiovascular risk factors, arterial stiffness is a recognized predictor of cardiovascular risk.

methodsWe investigated the relationship between traditional cardiovascular risk factors, sex, and aortic pulse wave velocity in subjects living in a countryside area of Southern Switzerland. For this aim, we performed a cross-sectional analysis of data from adult participants of the Swiss Longitudinal Cohort Study, which, initiated in 2015, follows health status and disease risk factors in a Swiss countryside cohort at least 6 years of age.

resultsA total of 387 people (205 women and 182 men) were included. Hyperlipidemia, overweight, and obesity were more common (p ≤ 0.001) and LDL-cholesterol, triglycerides, and hemoglobin A1c were higher (p < 0.03) in men than women. Systolic and diastolic brachial and aortic blood pressures were higher in men (p < 0.02), whereas aortic pulse wave velocity and aortic pulse pressure were higher in women (p < 0.05). The aortic pulse wave velocity was significantly higher in subjects with hypertension, hyperlipidemia, diabetes, and obesity, and significantly increased with age (p < 0.0001). Multiple linear regression analysis showed a significant correlation between pulse wave velocity and age, female sex, brachial systolic blood pressure, and heart rate (p < 0.005).

conclusionAlso in a countryside area, the aortic pulse wave velocity is higher in subjects with hypertension, hyperlipidemia, diabetes and obesity, and significantly increases with age. Furthermore, with advancing age, aortic pulse wave velocity is higher in women than men.

trial registrationClinicalTrials.gov identifier, NCT02282748.

Indexed as

Arterial hypertensionCardiovascular riskCountryPulse wave velocityRuralSex

Identifiers

PMID36152116
PMCPMC9652188
OpenAlexW4296977090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.