Evidence map›Paper›PMID 36152110›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2023

Updating our understanding of health-related quality of life issues in children with cancer: a systematic review of patient-reported outcome measures and qualitative studies.

Maria Rothmund, Samantha Sodergren, Gudrun Rohde, Teresa de Rojas, Gloria Paratico, Giorgia Albini, Johanna Mur, Anne-Sophie Darlington, Alessandra Majorana, David Riedl and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Usability Evaluation of the RevisedChildren (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria RothmundDivision of Psychiatry II, Department of Psychiatry, Psychotherapy, Psychosomatics, and Medical Psychology, Medical University Innsbruck, Innsbruck, Austria.
Samantha SodergrenSchool of Health Sciences, University of Southampton, Southampton, UK.
Gudrun RohdeDepartment of Clinical Research, Faculty of Health and Sport Sciences, Kristiansand and Sorlandet Hospital, University of Agder, Kristiansand, Norway.
Teresa de RojasACCELERATE, Europe, Brussels, Belgium.
Gloria ParaticoDepartment of Oral Medicine and Paediatric Dentistry, University of Brescia, Brescia, Italy.
Giorgia AlbiniDepartment of Oral Medicine and Paediatric Dentistry, University of Brescia, Brescia, Italy.
Johanna MurDivision of Psychiatry II, Department of Psychiatry, Psychotherapy, Psychosomatics, and Medical Psychology, Medical University Innsbruck, Innsbruck, Austria.
Anne-Sophie DarlingtonSchool of Health Sciences, University of Southampton, Southampton, UK.
Alessandra MajoranaDepartment of Oral Medicine and Paediatric Dentistry, University of Brescia, Brescia, Italy.
David RiedlDivision of Psychiatry II, Department of Psychiatry, Psychotherapy, Psychosomatics, and Medical Psychology, Medical University Innsbruck, Innsbruck, Austria. David.Riedl@i-med.ac.at.ORCID http://orcid.org/0000-0003-0518-3144
EORTC Quality of Life Group

Funding

European Organisation for Research and Treatment of Cancer 002-2020
6 · The paper itself

Abstract

backgroundHealth-related quality of life (HRQOL) is a key concept in pediatric oncology. This systematic review aims to update the conceptual HRQOL model by Anthony et al. (Qual Life Res 23(3):771-789, 2014), covering physical, emotional, social and general HRQOL aspects, and to present a comprehensive overview of age- and disease-specific HRQOL issues in children with cancer.

methodsMedline, PsychINFO, the Cochrane Database for Systematic Reviews (CDSR), and the COSMIN database were searched (up to 31.12.2020) for publications using patient-reported outcome measures (PROMs) and qualitative studies in children with cancer (8-14-year) or their parents. Items and quotations were extracted and mapped onto the conceptual model for HRQOL in children with cancer mentioned above.

resultsOf 2038 identified studies, 221 were included for data extraction. We identified 96 PROMS with 2641 items and extracted 798 quotations from 45 qualitative studies. Most items and quotations (94.8%) could be mapped onto the conceptual model. However, some adaptations were made and the model was complemented by (sub)domains for 'treatment burden', 'treatment involvement', and 'financial issues'. Physical and psychological aspects were more frequently covered than social issues. DISCUSSION: This review provides a comprehensive overview of HRQOL issues for children with cancer. Our findings mostly support the HRQOL model by Anthony et al. (Qual Life Res 23(3):771-789, 2014), but some adaptations are suggested. This review may be considered a starting point for a refinement of our understanding of HRQOL in children with cancer. Further qualitative research will help to evaluate the comprehensiveness of the HRQOL model and the relevance of the issues it encompasses.

Indexed as

NeoplasmsQuality of LifeChildHumansPatient Reported Outcome MeasuresQualitative ResearchChildren with cancerConcept elicitationHealth-related quality of lifePediatric oncologyQuality of life

Identifiers

PMID36152110
PMCPMC9510324

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.