ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2023
Porokeratosis is one of the most common genodermatoses and is associated with an increased risk of keratinocyte cancer and melanoma.
Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Malignant Transformation in Porokeratosis Ptychotropica: A Systematic Review.Acta dermato-venereologica · 2024Pooled it
- [Chronic hyperkeratotic plaques on the fingers and axillae in a mother and daughter].Dermatologie (Heidelberg, Germany) · 2026Article
- Efficacy and safety of topical statins for porokeratosis: a systematic review and practice-guided synthesis.Skin health and disease · 2026Review
- Systematized Linear Porokeratosis With Palmoplantar and Nail Involvement: A Rare Presentation.Cureus · 2026Article
- [Multiple squamous cell carcinomas arising in linear porokeratosis].Dermatologie (Heidelberg, Germany) · 2026Article
- First case of penile porokeratosis from Nepal: a case report.Annals of medicine and surgery (2012) · 2025Article
- Exploring MPM-FLIM for diagnostics of porokeratosis - a pilot studyBiomedical optics express · 2025Article
- Porokeratoses: an update on pathogenesis and treatment.International journal of dermatology · 2025Review
- Porokeratoses-A Rare Group of Dermatoses.Medicina (Kaunas, Lithuania) · 2024Review
- Disseminated Superficial Non-actinic Porokeratosis: A Consequence of Post-traumatic Immunosuppression.Cureus · 2024Article
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- Presentations of Cutaneous Disease in Various Skin Pigmentations: Porokeratosis.HCA healthcare journal of medicine · 2024Article
- A Case of Squamous Cell Carcinoma Arising in Disseminated Superficial Porokeratosis.Clinical, cosmetic and investigational dermatology · 2024Article
- Two Novel and Three Recurrent Mutations in the Mevalonate Pathway Genes in Chinese Patients with Porokeratosis.Clinical, cosmetic and investigational dermatology · 2024Article
- Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.Metabolites · 2023Review
- Incidence and Prevalence of 73 Different Genodermatoses: A Nationwide Study in Sweden.Acta dermato-venereologica · 2023Article
- Porokeratosis is one of the most common genodermatoses and is associated with an increased risk of keratinocyte cancer and melanoma.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPorokeratosis is a clinically heterogeneous group of keratinization disorders with a genetic background mainly affecting the mevalonate pathway, which is involved in the synthesis of cholesterol, an essential component for the formation of the extracellular lipid lamellae in the stratum corneum. Porokeratosis is reportedly associated with an increased risk of keratinocyte cancer, but to date, no large epidemiological studies have been conducted to further address this association.
objectivesThe first objective was to characterize a cohort of patients diagnosed with porokeratosis at the Department of Dermatology and Venereology, Sahlgrenska University Hospital (SU), Gothenburg, Sweden. The second objective was to conduct a nationwide registry-based cohort study to investigate the association, if any, between porokeratosis and the cutaneous malignancies squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma.
methodsFor the SU cohort, the hospital registry was searched for patients with a diagnosis of porokeratosis recorded between 2016 and 2020. Clinical data were extracted from the records of the identified patients. For the nationwide cohort, national registries were searched to identify patients with a diagnosis of porokeratosis between 2001 and 2020. A tenfold control cohort was formed by Statistics Sweden. The data was cross-referenced with the Swedish Cancer Register to study the associations between porokeratosis and SCC, BCC and melanoma.
resultsDisseminated superficial actinic porokeratosis was the most common clinical type among the 108 patients in the SU cohort. In the nationwide search, 2277 patients with porokeratosis were identified (prevalence 1/4132). Porokeratosis was associated with an increased risk for SCC, BCC and melanoma with hazard ratios (95% CI) of 4.3 (3.4-5.4), 2.42 (1.97-2.98) and 1.83 (1.18-2.82), respectively, in the patient cohort, compared to the matched control group.
conclusionPorokeratosis is a common genodermatosis, and it is associated with an enhanced risk of skin cancer.
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