Evidence map›Paper›PMID 36151969›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2023

The significance of TNF-α and MMP-8 concentrations in non-invasively obtained amniotic fluid predicting fetal inflammatory response syndrome.

Violeta Gulbiniene, Greta Balciuniene, Irena Dumalakiene, Rita Viliene, Ingrida Pilypiene, Diana Ramasauskaite

Open access · hybridAbstract read
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In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Functional MRI assessment of the lungs in fetuses that deliver very Preterm: An MRI pilot study.European journal of obstetrics, gynecology, and reproductive biology · 2024
    Article
  4. Article
  5. The significance of TNF-α and MMP-8 concentrations in non-invasively obtained amniotic fluid predicting fetal inflammatory response syndrome.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Violeta GulbinieneCenter of Obstetrics and Gynaecology, Institute of Clinical Medicine of the Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-2506-521X
Greta BalciunieneCenter of Obstetrics and Gynaecology, Institute of Clinical Medicine of the Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Irena DumalakieneState Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Rita VilieneState Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Ingrida PilypieneCenter of Obstetrics and Gynaecology, Institute of Clinical Medicine of the Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Diana RamasauskaiteCenter of Obstetrics and Gynaecology, Institute of Clinical Medicine of the Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Vilnius University · LTState Research Institute Centre for Innovative Medicine · LT

Funding

Research Council of Lithuania (RCL) S-MIP-19-57
6 · The paper itself

Abstract

objectiveTo determine the significance of tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-8 (MMP-8) in vaginally obtained amniotic fluid predicting fetal inflammatory response syndrome (FIRS) after preterm premature rupture of membranes (PPROM).

methodsIn this prospective case-control study, TNF-α and MMP-8 concentrations were evaluated in vaginally obtained amniotic fluid from women with PPROM at 22-34 weeks of pregnancy. Biomarkers' concentrations were determined using an enzyme-linked immunosorbent assay. Patients were divided into two groups: the FIRS group (cord blood interleukin-6 > 11 pg/ml or histological funisitis) and the non-FIRS group (without these findings). The data were analyzed using R package (R-4.0.5).

resultsThe median TNF-α and MMP-8 concentrations in amniotic fluid from the 145 women included in the study were higher in the FIRS group than in the non-FIRS group. The area under the curve of TNF-α and MMP-8 was 0.77 and 0.75, respectively. The TNF-α concentration cut-off predicting FIRS was 89.20 pg/ml and was 170.76 pg/ml for MMP-8. In regression analysis, MMP-8 concentration was an independent predictor for FIRS. An MMP-8 concentration greater than 170 ng/ml and a TNF-α concentration greater than 89 pg/ml increased the odds of FIRS 7.62 and 14.92 times, respectively.

conclusionsMMP-8 and TNF-α concentrations in vaginally obtained amniotic fluid may be good predictors for FIRS after PPROM before 34 weeks of pregnancy. The non-invasive amniotic fluid analysis could be an alternative method to invasive amniocentesis.

Indexed as

ChorioamnionitisPremature Rupture of Fetal MembranesAmniotic FluidCase-Control StudiesFemaleFetal DiseasesHumansInfant, NewbornMatrix Metalloproteinase 8PregnancySystemic Inflammatory Response SyndromeTumor Necrosis Factor-alphaMatrix Metalloproteinase 8Tumor Necrosis Factor-alphaamniotic fluidbiomarkerfetal inflammatory response syndrome (FIRS)matrix metalloproteinase-8 (MMP-8)non-invasive methodpreterm birthpreterm premature rupture of membranes (PPROM)tumor necrosis factor-α (TNF-α)

Identifiers

PMID36151969
PMCPMC10092754
OpenAlexW4296931712

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.