ArticleESC heart failure2023
Risk factors for pre-heart failure or symptomatic heart failure based on NT-proBNP.
Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Diagnostic Tests for Stage B Heart Failure.Current cardiology reports · 2026Review
- Guideline-Based Elevated NT-proBNP Among Asymptomatic Adults with Diabetes in Saudi Arabia: Prevalence and Real-World Clinical Correlates.Advances in therapy · 2026Article
- Association of home blood pressure with asymptomatic Stage B heart failure determined by cardiac biomarkers.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Developing a risk score for B-type natriuretic peptide (BNP) ≥ 100 pg/ml levels: the suita study.BMC cardiovascular disorders · 2025Article
- NT-proBNP improves prediction of cardiorenal complications in type 2 diabetes: the Hong Kong Diabetes Biobank.Diabetologia · 2025Article
- The Role of NT-proBNP Levels in the Diagnosis of Hypertensive Heart Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Life-course obesity and heart failure: a two-sample Mendelian randomization study.Internal and emergency medicine · 2025Article
- Risk factors for pre-heart failure or symptomatic heart failure based on NT-proBNP.ESC heart failure · 2023Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
aimsEvidence on the risk factors for incident heart failure in Asia has been limited. We sought to identify the risk factors for pre-heart failure or symptomatic heart failure, based on N-terminal pro-B-type natriuretic peptide (NT-proBNP), in the Japanese general population.
methodsWe performed a retrospective cohort study based on the Circulatory Risk in Communities Study involving 5335 Japanese individuals whose NT-proBNP levels were measured between 2010 and 2015. Of these, 2768 people aged between 30 and 69 years who undertook annual cardiovascular risk surveys at least once between 1990 and 2000 were retrospectively eligible to be participants in this study. We performed multivariable logistic regression analyses to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of pre-heart failure or symptomatic heart failure defined as NT-proBNP >400 pg/mL or as having a diagnosis of heart failure and taking medication for heart failure for several cardiovascular risk factors (body mass index, blood pressure, diabetes mellitus, total cholesterol, triglyceride, smoking status, drinking status).
resultsWe identified 85 cases of heart failure. The multivariable ORs (95% CIs) were 5.70 (2.70-12.0) for body mass index of 27-29.9 kg/m
conclusionsThe accumulation of these risk factors was associated with a graded higher risk of pre-heart failure or symptomatic heart failure.
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