Evidence map›Paper›PMID 36151614›Full record

ArticlePhysiological reports2022

Ammonium chloride-induced acidosis exacerbates cystitis and pyelonephritis caused by uropathogenic E. coli.

Jeffrey M Purkerson, Coralee A Everett, George J Schwartz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Unusual case ofFrontiers in cellular and infection microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeffrey M PurkersonPediatric Nephrology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-7636-4992
Coralee A EverettPediatric Nephrology, University of Rochester Medical Center, Rochester, New York, USA.
George J SchwartzPediatric Nephrology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-8291-1355
University of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pyelonephritis caused by uropathogenic E. coli (UPEC) can cause renal scarring and lead to development of chronic kidney disease. Prevention of kidney injury requires an understanding of host factors and/or UPEC adaptive responses that are permissive for UPEC colonization of the urinary tract. Although some studies have suggested urine acidification limits UPEC growth in culture, other studies have described acid-resistance mechanisms (AR) in E. coli such as the CadC/CadBA module that promotes adaptation to acid and nitrosative stress. Herein we confirm and extend our previous study by demonstrating that despite urine acidification, metabolic acidosis induced by dietary ammonium chloride (NH

Indexed as

AcidosisCystitisEscherichia coli InfectionsPyelonephritisUrinary Tract InfectionsUropathogenic Escherichia coliAmmonium ChlorideAnimalsArginineChemokinesCytokinesHydrochloric AcidMiceMice, Inbred C3HNitric OxidePolyaminesAmmonium ChlorideArginineChemokinesCytokinesHydrochloric AcidNitric OxidePolyaminesRNA, MessengerToll-Like Receptor 4acid-base physiologyinflammationkidney collecting ducturinary tract infectionuropathogenic E. coli

Identifiers

PMID36151614
PMCPMC9508385
OpenAlexW4297184525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.