Evidence map›Paper›PMID 36151345›Full record

ReviewPflugers Archiv : European journal of physiology2022

The impact of progredient vessel and tissue stiffening for the development of metabolic syndrome.

Clemens Loracher, Bruno Märkl, Alois Loracher

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Clemens LoracherGeneral Pathology and Molecular Diagnostics, Medical Faculty, University Augsburg, Stenglinstrasse 2, 86156, Augsburg, Germany. clemens.loracher@uka-science.de.ORCID 0000-0002-0550-6612
Bruno MärklGeneral Pathology and Molecular Diagnostics, Medical Faculty, University Augsburg, Stenglinstrasse 2, 86156, Augsburg, Germany.ORCID 0000-0002-7704-850X
Alois LoracherGeneral Pathology and Molecular Diagnostics, Medical Faculty, University Augsburg, Stenglinstrasse 2, 86156, Augsburg, Germany.
University of Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Established risk factors for the metabolic syndrome as diabetes and arterial hypertension are believed to be the cause of arteriosclerosis and subsequently following diseases like coronary heart disease, apoplexy, or chronic renal failure. Based on broad evidence from the already available experimental literature and clinical experience, an alternative hypothesis is presented that puts an increased vessel and organ stiffness to the beginning of the pathophysiological scenario. The stiffness itself is caused by a persistent activation of mechano-sensitive cation channels like the epithelial/endothelial sodium channel. A further enhancement takes place by proteins like JACD and RhoA coupled phospholipase C coupled G-protein receptors and integrins. A self-enhancing positive feedback loop by activation of YAP/TAZ signaling is a further central pillar of this theory. Further investigations are necessary to verify this hypothesis. If this hypothesis could be confirmed fundamental changes regarding the pharmacologic therapy of the diseases that are currently summarizes as metabolic syndrome would be the consequence.

Indexed as

Metabolic SyndromeVascular StiffnessDiabetes MellitusEpithelial Sodium ChannelsHumansHypertensionSignal TransductionTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling ProteinsEpithelial Sodium ChannelsTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling ProteinsArteriosclerosisMechanosensitive cation channelsMetabolic syndromeStiffness

Identifiers

PMID36151345
PMCPMC9663348
OpenAlexW4297018013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.