Evidence map›Paper›PMID 36151295›Full record

ArticlePediatric research2023

Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70

Hilde D de Vries, Anna Palmiotti, Rumei Li, Milaine V Hovingh, Niels L Mulder, Martijn Koehorst, Vincent W Bloks, Tim van Zutphen, Folkert Kuipers, Jan Freark de Boer

Open access · hybridAbstract read
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response inAmerican journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hilde D de VriesDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Anna PalmiottiDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Rumei LiDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Milaine V HovinghDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Niels L MulderDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Martijn KoehorstDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Vincent W BloksDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Tim van ZutphenFaculty Campus Fryslân, University of Groningen, Leeuwarden, The Netherlands.
Folkert KuipersDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jan Freark de BoerDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. j.f.de.boer@umcg.nl.
University Medical Center Groningen · NLUniversity of Groningen · NLFryske Akademy · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyp2c70

methodsCyp2c70

resultsThree-week-old Cyp2c70

conclusionPerinatal exposure of Cyp2c70 IMPACT: This is the first study showing that perinatal UDCA exposure prevents features of neonatal cholestasis that are observed in mice with a human-like bile acid composition, i.e., Cyp2c70

Indexed as

CholestasisLiver DiseasesAnimalsBile Acids and SaltsFemaleHumansInfant, NewbornMaleMicePregnancyUrsodeoxycholic AcidBile Acids and SaltsUrsodeoxycholic Acid

Identifiers

PMID36151295
PMCPMC10172110
OpenAlexW4297020355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.