ArticleScientific reports2022
Fertility costs of cryptic viral infections in a model social insect.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Fertility Management in Pollinators: Queen Storage, Transport, and Reproductive Resilience inInsects · 2026Review
- Pheromone and morphometric features of honey bee (Apis mellifera) queens imported to Canada from around the globe.PloS one · 2026Article
- Elevated virus infection of honey bee queens reduces methyl oleate production and destabilizes colony-level social structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Honey bee egg composition changes seasonally and after acute maternal virus infection.Scientific reports · 2025Article
- Review
- Differences in honeybee queen pheromones revealed by LC-MS/MS: Reassessing the honest signal hypothesis.iScience · 2024Article
- Common viral infections inhibit egg laying in honey bee queens and are linked to premature supersedure.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Declining insect populations emphasize the importance of understanding the drivers underlying reductions in insect fitness. Here, we investigated viruses as a threat to social insect reproduction, using honey bees as a model species. We report that in two independent surveys (N = 93 and N = 54, respectively) of honey bee (Apis mellifera) queens taken from a total of ten beekeeping operations across British Columbia, high levels of natural viral infection are associated with decreased ovary mass. Failed (poor quality) queens displayed higher levels of viral infection, reduced sperm viability, smaller ovaries, and altered ovary protein composition compared to healthy queens. We experimentally infected queens with Israeli acute paralysis virus (IAPV) and found that the ovary masses of IAPV-injected queens were significantly smaller than control queens, demonstrating a causal relationship between viral infection and ovary size. Queens injected with IAPV also had significantly lower expression of vitellogenin, the main source of nutrition deposited into developing oocytes, and higher levels of heat-shock proteins, which are part of the honey bee's antiviral response. This work together shows that viral infections occurring naturally in the field are compromising queen reproductive success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.