ArticleScientific reports2022
Actin cable formation and epidermis-dermis positional relationship during complete skin regeneration.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- The basement membrane determines the choice of wound healing mechanism across wound scales in the basal eukaryoteMolecular biology of the cell · 2026Article
- Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro.International journal of cosmetic science · 2026Article
- Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration.Nature communications · 2025Article
- Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects.Science advances · 2025Article
- Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing.Biological procedures online · 2025Article
- Actin mesh in Re-epithelialization during skin regeneration in adult newt (Regenerative therapy · 2025Article
- Integrated proteomics highlights functional activation induced by advanced-platelet rich fibrin plus (A-PRF +) in primary equine fibroblasts.Scientific reports · 2025Article
- Article
- Rac1 inhibition regenerates wounds in mouse fetuses via altered actin dynamics.Scientific reports · 2024Article
- Article
- Tunneling nanotube-driven complete regeneration of murine fetal skin.Scientific reports · 2024Article
- Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice.Scientific reports · 2024Article
- Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses.Scientific reports · 2024Article
- Regeneration of Panniculus Carnosus Muscle in Fetal Mice Is Characterized by the Presence of Actin Cables.Biomedicines · 2023Article
- Article
- Fetal Fibroblast Transplantation via Ablative Fractional Laser Irradiation Reduces Scarring.Biomedicines · 2023Article
- Effect of Sonic Hedgehog on the Regeneration of Epidermal Texture Patterns.Biomedicines · 2022Article
- Dendritic Cell-Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Up to a certain developmental stage, a fetus can completely regenerate wounds in the skin. To clarify the mechanism of fetal skin regeneration, identifying when the skin switches from fetal-type wound regeneration to adult-type wound repair is necessary. We hypothesized that this switch occurs at several time points and that complete skin regeneration requires epidermal-dermal interactions and the formation of actin cables. We compared normal skin and wound morphology at each developmental stage. We examined two parameters: epidermal texture and dermal structure. We found that the three-dimensional structure of the skin was completely regenerated in full-thickness skin incisions made before embryonic day (E) 13. However, the skin texture did not regenerate in wounds made after E14. We also found that the dermal structure regenerates up to E16, but wounds created after E17 heal as scars with dermal fibrosis. By controlling the activity of AMP-activated protein kinase and altering actin cable formation, we could regulate scar formation in utero. These findings may contribute to therapies that allow complete skin regeneration without scarring.
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Registered trials
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