Evidence map›Paper›PMID 36151099›Full record

ArticleNature communications2022

Household transmission of the SARS-CoV-2 Omicron variant in Denmark.

Frederik Plesner Lyngse, Laust Hvas Mortensen, Matthew J Denwood, Lasse Engbo Christiansen, Camilla Holten Møller, Robert Leo Skov, Katja Spiess, Anders Fomsgaard, Ria Lassaunière, Morten Rasmussen and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 5 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Antigen Testing (January 2023).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Guideline
  2. Pooled it
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  5. The role of children in transmission of SARS-CoV-2 variants of concern within households: an updated systematic review and meta-analysis, as at 30 June 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Pooled it
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  14. Genomic Surveillance of SARS-CoV-2 in Ibadan, Oyo State, Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Frederik Plesner LyngseDepartment of Economics & Center for Economic Behavior and Inequality, University of Copenhagen, Øster Farimagsgade 5, DK-1353, Copenhagen K, Denmark. fpl@econ.ku.dk.ORCID 0000-0002-0584-6115
Laust Hvas MortensenStatistics Denmark, Sejrøgade 11, DK-2100, Copenhagen, Denmark.
Matthew J DenwoodDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 8, DK-1870, Frederiksberg C, Copenhagen, Denmark.ORCID 0000-0001-5212-4273
Lasse Engbo ChristiansenDepartment of Applied Mathematics and Computer Science, Dynamical Systems, Technical University of Denmark, Richard Petersens Plads, 324, DK-2800, Kgs. Lyngby, Denmark.ORCID 0000-0001-5019-1931
Camilla Holten MøllerStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.
Robert Leo SkovStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0002-6079-5381
Katja SpiessStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0002-2388-4617
Anders FomsgaardStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0003-4304-0603
Ria LassaunièreStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0002-3910-7185
Morten RasmussenStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.
Marc SteggerDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0003-0321-1180
Claus NielsenStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.
Raphael Niklaus SieberDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0002-0372-128X
Arieh Sierra CohenStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.
Frederik Trier MøllerStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0002-1059-4661
Maria OvervadStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.
Kåre MølbakStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.ORCID 0000-0002-3100-4990
Tyra Grove KrauseStatens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.
Carsten Thure KirkebyDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 8, DK-1870, Frederiksberg C, Copenhagen, Denmark.
Statens Serum Institut · DKUniversity of Copenhagen · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.

Indexed as

COVID-19SARS-CoV-2DenmarkFamily CharacteristicsHumans

Identifiers

PMID36151099
PMCPMC9508106
OpenAlexW4296831823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.