Evidence map›Paper›PMID 36150761›Full record

ArticleKidney international2022

Lupus nephritis transcriptomics across space and time.

Shaun W Jackson, Charles E Alpers

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shaun W JacksonSeattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Charles E AlpersDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA. Electronic address: calp@u.washington.edu.

Funding

RESEARCH TRAINING IN RHEUMATOLOGYT32AR007108 · NIAMS · UNIVERSITY OF WASHINGTON · PI Shaun Jackson, Tomas M Mustelin · 1986 to 2026
$6.6M
Mechanistic insights into systemic lupus erythematosus (SLE) pathogenesis from inborn errors of immunityR01AR073938 · NIAMS · SEATTLE CHILDREN'S HOSPITAL · PI Shaun William Jackson · 2019 to 2026
$4.0M
Impact of Loss-of-function NADPH Oxidase Variants on B-Cell Activation in SLER01AR075813 · NIAMS · SEATTLE CHILDREN'S HOSPITAL · PI JACKSON, SHAUN WILLIAM · 2021 to 2025
$2.8M
NIAMS NIH HHS R01 AR073938NIAMS NIH HHS R01 AR075813NIAMS NIH HHS T32 AR007108
6 · The paper itself

Abstract

Current immunosuppression regimens for lupus nephritis are incompletely effective, placing patients at risk for poor long-term outcomes. This emphasizes the need to dissect pathogenic mechanisms in lupus nephritis, to inform the development of targeted therapies. In this issue of Kidney International, Parikh et al. performed transcriptomic analysis of pretreatment and posttreatment protocol kidney biopsies, segregated into glomerular and tubulointerstitial compartments, to identify candidate molecular pathways distinguishing treatment responders and nonresponders.

Indexed as

Lupus NephritisHumansKidneyKidney GlomerulusTranscriptome

Identifiers

PMID36150761
PMCPMC11639589

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.