Evidence map›Paper›PMID 36150719›Full record

ArticleJournal of industrial microbiology & biotechnology2022

Bioindustrial manufacturing readiness levels (BioMRLs) as a shared framework for measuring and communicating the maturity of bioproduct manufacturing processes.

Michael J Smanski, Aristos Aristidou, Ryan Carruth, John Erickson, Mark Gordon, Sandeep B Kedia, Kelvin H Lee, Darcy Prather, John E Schiel, Heather Schultheisz and 4 more

Abstract read
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael J SmanskiBioMADE, Saint Paul, MN 55108, USA.ORCID 0000-0002-6029-8326
Aristos AristidouCargill, Incorporated, Minneapolis, MN 55391, USA.
Ryan CarruthSuperbrewed Foods, Incorporated, New Castle, DE 19720, USA.
John EricksonNational Institute of Innovation in Manufacturing Biopharmaceuticals, Newark, DE 19713, USA.
Mark GordonMfg Strategy, Inc., Tampa, FL 33613, USA.
Sandeep B KediaNational Institute of Innovation in Manufacturing Biopharmaceuticals, Newark, DE 19713, USA.
Kelvin H LeeNational Institute of Innovation in Manufacturing Biopharmaceuticals, Newark, DE 19713, USA.
Darcy PratherKalion, Incorporated, Milton, MA 02186, USA.
John E SchielNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Heather SchultheiszGenomatica, Inc., San Diego, CA 92121,USA.
Thomas P TreynorR2DIO Inc., Berkeley, CA 94702-1102, USA.
Steven L EvansBioMADE, Saint Paul, MN 55108, USA.
Douglas C FriedmanBioMADE, Saint Paul, MN 55108, USA.
Melanie TomczakBioMADE, Saint Paul, MN 55108, USA.

Funding

United States Air Force FA8650-21-2-5028
6 · The paper itself

Abstract

Readiness level (RL) frameworks such as technology readiness levels and manufacturing readiness levels describe the status of a technology/manufacturing process on its journey from initial conception to commercial deployment. More importantly, they provide a roadmap to guide technology development and scale-up from a ''totality of system'' approach. Commercialization risks associated with too narrowly focused R&D efforts are mitigated. RLs are defined abstractly so that they can apply to diverse industries and technology sectors. However, differences between technology sectors make necessary the definition of sector specific RL frameworks. Here, we describe bioindustrial manufacturing readiness levels (BioMRLs), a classification system specific to bioindustrial manufacturing. BioMRLs will give program managers, investors, scientists, and engineers a shared vocabulary for prioritizing goals and assessing risks in the development and commercialization of a bioindustrial manufacturing process.

Indexed as

IndustryTechnologyBioeconomyBioindustrial manufacturingBioMRLBioproduct

Identifiers

PMID36150719
PMCPMC9559305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.