Evidence map›Paper›PMID 36150235›Full record

ArticleExpert review of neurotherapeutics2022

Considering hearing loss as a modifiable risk factor for dementia.

Katharine K Brewster, Jennifer A Deal, Frank R Lin, Bret R Rutherford

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Expert review of neurotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06495268 (Healthy Hearing for Healthy Ageing), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06495268 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Healthy Hearing for Healthy Ageing: a Proof-of-concept Randomized Controlled Trial of Data-driven Hearing Rehabilitation Versus Standard Care in Older Adults With Hearing Impairment.

TypeinterventionalSponsorKuopio University HospitalRan2024 to 2028Enrolled200ConditionsSensorineural Hearing Loss, Cognitive DeclineArmsIndividualised data-driven hearing rehabilitation, Standard care hearing rehabilitation
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katharine K BrewsterColumbia University Vagelos College of Physicians and Surgeons, Department of Psychiatry, New York State Psychiatric Institute, New York.
Jennifer A DealDepartment of Otolaryngology, Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Johns Hopkins University, Center on Aging and Health, Johns Hopkins University School of Medicine.
Frank R LinDepartment of Otolaryngology, Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Johns Hopkins University School of Medicine.
Bret R RutherfordColumbia University Vagelos College of Physicians and Surgeons, Department of Psychiatry, New York State Psychiatric Institute, New York, USA.
Columbia University · USJohns Hopkins University · US

Funding

Research Training in Late-Life NeuroPsychiatric DisordersT32MH020004 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Patrick J Brown · 1998 to 2026
$6.1M
NIMH NIH HHS T32 MH020004
6 · The paper itself

Abstract

introductionAccumulating evidence links hearing loss to impaired cognitive performance and increased risk for dementia. Hearing loss can lead to deafferentation-induced atrophy of frontotemporal brain regions and dysregulation of cognitive control networks from increased listening effort. Hearing loss is also associated with reduced social engagement, loneliness, and depression, which are independently associated with poor cognitive function. AREAS COVERED: We summarize the evidence and postulated mechanisms linking hearing loss to dementia in older adults and synthesize the available literature demonstrating beneficial effects of hearing remediation on brain structure and function. EXPERT OPINION: : Further research is needed to evaluate whether treatment of hearing loss may reduce risk of cognitive decline and improve neural consequences of hearing loss. Studies may investigate the pathologic mechanisms linking these late-life disorders and identify individuals vulnerable to dementia, and future clinical trials may evaluate whether hearing treatment may reduce the risk for dementia.

Indexed as

Cognitive DysfunctionDementiaHearing LossAgedCognitionHumansRisk FactorsCognitive declinedementiahearing aidshearing lossmodifiable risk factor

Identifiers

PMID36150235
PMCPMC9647784
OpenAlexW4297037889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.