ArticleObesity (Silver Spring, Md.)2022
Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity.
Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Mediating effect of gestational weight gain on the preventive effect of exercise during pregnancy on macrosomia: a randomized clinical trial.BMC pregnancy and childbirth · 2024Trial
- Gestational weight gain and perinatal outcomes in twin pregnancies: evidence-based insights from a Chinese population cohort.Annals of medicine · 2026Observational
- Abnormal fasting glucose levels in the diagnosis of GDM may be associated with adverse pregnancy outcomes.Archives of gynecology and obstetrics · 2026Observational
- Identifying critical windows for macrosomia prevention: a study on the association between phase-specific dynamic BMI changes and macrosomia risk.Frontiers in endocrinology · 2026Article
- Individual Prediction of Insulin Therapy in Gestational Diabetes: Development of a Risk Calculator Based on Real-World Data from the GestDiab Registry.Geburtshilfe und Frauenheilkunde · 2025Article
- Recent Insights and Recommendations for Preventing Excessive Gestational Weight Gain.Journal of clinical medicine · 2024Review
- The Role of the Glycemic Index and Glycemic Load in the Dietary Approach of Gestational Diabetes Mellitus.Nutrients · 2024Review
- Article
- Insulin Sensitivity and β-Cell Function During Early and Late Pregnancy in Women With and Without Gestational Diabetes Mellitus.Diabetes care · 2023Article
- Weight progression and adherence to weight gain target in women with vs. without gestational diabetes: a retrospective cohort study.BMC pregnancy and childbirth · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveObesity increases the risk for pregnancy complications and maternal hyperglycemia. The Institute of Medicine developed guidelines for gestational weight gain (GWG) targets for women with overweight/obesity, but it is unclear whether exceeding these targets has adverse effects on maternal glucose metabolism.
methodsInsulin sensitivity (assessed using the Matsuda Insulin Sensitivity Index), β-cell function (assessed as insulin secretion rate in relation to plasma glucose), and plasma insulin clearance rate were evaluated using a frequently sampled oral glucose tolerance test at 15 and 35 weeks of gestation in 184 socioeconomically disadvantaged African American women with overweight/obesity.
resultsInsulin sensitivity decreased, whereas β-cell function and insulin clearance increased from 15 to 35 weeks of gestation in the entire group. Compared with women who achieved the recommended GWG, excessive GWG was associated with a greater decrease in insulin sensitivity between 15 and 35 weeks. β-cell function and plasma insulin clearance were not affected by excessive GWG.
conclusionsThese data demonstrate that gaining more weight during pregnancy than recommended by the Institute of Medicine is associated with functional effects on glucose metabolism.
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Registered trials
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