Evidence map›Paper›PMID 36149846›Full record

ArticlePLoS neglected tropical diseases2022

Phylogeographic patterns of the yellow fever virus around the metropolitan region of São Paulo, Brazil, 2016-2019.

Marielton Dos Passos Cunha, Amaro Nunes Duarte-Neto, Shahab Zaki Pour, Bárbara Brito de Souza Pereira, Yeh-Li Ho, Beatriz Perondi, Jaques Sztajnbok, Venancio Avancini Ferreira Alves, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marielton Dos Passos CunhaLaboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-2102-631X
Amaro Nunes Duarte-NetoPathology Department, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-6659-7186
Shahab Zaki PourLaboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-7708-1406
Bárbara Brito de Souza PereiraLaboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Yeh-Li HoIntensive Care Unit, Division of Clinical Infectious and Parasitic Diseases, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-8719-2508
Beatriz PerondiYellow Fever Crisis Committee, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-2280-642X
Jaques SztajnbokInstitute of Infectology Emílio Ribas, São Paulo, Brazil.ORCID 0000-0002-3188-8044
Venancio Avancini Ferreira AlvesPathology Department, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-5285-4460
Luiz Fernando Ferraz da SilvaPathology Department, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Marisa DolhnikoffPathology Department, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-9073-9989
Paulo Hilário Nascimento SaldivaPathology Department, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Paolo Marinho de Andrade ZanottoLaboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-8167-0625

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From 2016 to 2019, the largest outbreak caused by the Yellow Fever virus (YFV) in the 21st century in the Americas occurred in southeastern Brazil. A sylvatic cycle of transmission was reported near densely populated areas, such as the large metropolitan area of the city of São Paulo. Here, we describe the origin, spread, and movement of the YFV throughout the state of São Paulo. Whole-genome sequences were obtained from tissues of two patients who died due to severe yellow fever, during 2018-2019. Molecular analysis indicated that all analyzed tissues were positive for YFV RNA, with the liver being the organ with the highest amount of viral RNA. Sequence analysis indicates that genomes belonged to the South American genotype I and were grouped in the epidemic clade II, which includes sequences from the states of Goiás, Minas Gerais, and São Paulo of previous years. The analysis of viral dispersion indicates that the outbreak originated in Goiás at the end of 2014 and reached the state of São Paulo through the state of Minas Gerais after 2016. When the virus reached near the urban area, it spread towards both the east and south regions of the state, not establishing an urban transmission cycle in the metropolitan region of São Paulo. The virus that moved towards the east met with YFV coming from the south of the state of Rio de Janeiro, and the YFV that was carried to the south reached the Brazilian states located in the south region of the country.

Indexed as

Yellow FeverYellow fever virusBrazilDisease OutbreaksHumansPhylogeographyRNA, ViralRNA, Viral

Identifiers

PMID36149846
PMCPMC9506654

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.