Evidence map›Paper›PMID 36149830›Full record

ArticleEmerging microbes & infections2022

Medium-term outcomes of myocarditis and pericarditis following BNT162b2 vaccination among adolescents in Hong Kong.

Gilbert T Chua, Sabrina Tsao, Mike Yat Wah Kwan, Tak Ching Yu, Agnes Sze Yin Leung, Ka Wah Li, Calvin Chit Kwong Chow, Wai Hung Ku, Janette Kwok, Kelvin K W To and 4 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Gilbert T ChuaDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-0333-0059
Sabrina TsaoDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Mike Yat Wah KwanDepartment of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Hong Kong SAR, People's Republic of China.
Tak Ching YuDepartment of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People's Republic of China.
Agnes Sze Yin LeungDepartment of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.
Ka Wah LiDepartment of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Hong Kong SAR, People's Republic of China.
Calvin Chit Kwong ChowDepartment of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong SAR, People's Republic of China.
Wai Hung KuDepartment of Paediatrics and Adolescent Medicine, Tseng Kwan O Hospital, Hong Kong SAR, People's Republic of China.
Janette KwokDivision of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-0038-1897
Kelvin K W ToDepartment of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-1921-5824
Yu Lung LauDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-4780-0289
Francisco Tsz Tsun LaiCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-9121-1959
Ian Chi Kei WongCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0001-8242-0014
Patrick IpDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-6797-6898
Chinese University of Hong Kong · HKPamela Youde Nethersole Eastern Hospital · CNPrincess Margaret Cancer Centre · CAQueen Mary Hospital · CNTseung Kwan O Hospital · CNTuen Mun Hospital · CNUnited Christian Hospital · CNUniversity College London · GBUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we examined the clinical and electrophysiological outcomes of adolescents in Hong Kong who developed myocarditis or pericarditis following BNT162b2 vaccination for COVID-19, and followed-up for 60-180 days after their initial diagnosis. Clinical assessments included electrocardiogram (ECG) and echocardiogram at the initial admission and follow-up were compared. Treadmill testing was also performed in some cases. Between 14 June 2021 and 16 February 2022, 53 subjects were approached to participate in this follow-up study, of which 28 patients were followed up for >60 days with a median follow-up period of 100 days (range, 61-178 days) and were included in this study. On admission, 23 patients had ECG abnormalities but no high-grade atrioventricular block. Six patients had echocardiogram abnormalities, including reduced contractility, small rim pericardial effusions, and hyperechoic ventricular walls. All patients achieved complete recovery on follow-up. After discharge, 10 patients (35.7%) reported symptoms, including occasional chest pain, shortness of breath, reduced exercise tolerance, and recurrent vasovagal near-syncope. At follow-up, assessments, including ECGs, were almost all normal. Among the three patients with possible ECG abnormalities, all their echocardiograms or treadmill testings were normal. Sixteen patients (57.1%) underwent treadmill testing at a median of 117 days post-admission, which were also normal. However, at follow-up, there was a significant mean bodyweight increase of 1.81 kg (95%CI 0.47-3.1 kg,

Indexed as

BNT162 VaccineCOVID-19MyocarditisPericarditisAdolescentFollow-Up StudiesHong KongHumansVaccinationBNT162 VaccineAdolescentsBNT162b2COVID-19medium-termmyocarditis

Identifiers

PMID36149830
PMCPMC9621237
OpenAlexW4296797530

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.