ReviewEuropean journal of microbiology & immunology2022
Antibacterial effects of vanilla ingredients provide novel treatment options for infections with multidrug-resistant bacteria - A recent literature review.
Review in European journal of microbiology & immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed.
- Synthesis, Antibacterial Evaluation, and Chemometric Profiling of a Vanilloid-Based Compounds Library Active AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Shikimic acid pathway drives the phase-dependent antibacterial activity of Bacillus amyloliquefaciens against Xanthomonas citri subsp. citri.BMC microbiology · 2026Article
- Integrated chemical and biological characterization of Hypericum perforatum extract using LC-MS/MS and in vitro functional assays.Scientific reports · 2026Article
- The therapeutic potential ofFrontiers in pharmacology · 2026Review
- Development of electrochemical sensor for vanillin determination using carbon spheres-LaFeScientific reports · 2025Article
- Natural Hydroxybenzoic and Hydroxycinnamic Acids Derivatives: Mechanisms of Action and Therapeutic Applications.Antioxidants (Basel, Switzerland) · 2025Review
- Comprehensive metabolome characterization of leaves, internodes, and aerial roots of Vanilla planifolia by untargeted LC-MS and GC × GC-MS.Phytochemical analysis : PCA · 2025Article
- Phenolic Characterization and Quality Evaluation of Herbal Coffee from Roasted Juniper Berry Fruits (Foods (Basel, Switzerland) · 2024Article
- Article
- Biological Nitrification Inhibitors with Antagonistic and Synergistic Effects on Growth of Ammonia Oxidisers and Soil Nitrification.Microbial ecology · 2024Article
- Identifying Potential Natural Antibiotics from Unani Formulas through Machine Learning Approaches.Antibiotics (Basel, Switzerland) · 2024Article
- Metabolome fingerprinting reveals the presence of multiple nitrification inhibitors in biomass and root exudates ofPlant-environment interactions (Hoboken, N.J.) · 2024Article
- Evaluation of Bioactive Compounds and Antioxidant and Cytotoxic Effects of Oil and Pulp without Açaí Fat (Foods (Basel, Switzerland) · 2024Article
- Characterization of antibiotic and disinfectant susceptibility in biofilm-forming Acinetobacter baumannii: A focus on environmental isolates.European journal of microbiology & immunology · 2024Article
- Article
- Evaluation of surface roughness, cytotoxicity, and antibacterial effects of silver nanoparticle coating on copper nickel titanium orthodontic arch wires -Journal of orthodontic science · 2024Article
- Spices as Sustainable Food Preservatives: A Comprehensive Review of Their Antimicrobial Potential.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Antibacterial mechanism of vanillin againstHeliyon · 2023Article
- Decolorized and Undecolorized Ethanol Extracts of Ginggiyang (Food technology and biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the increasing application of antibiotics not only in healthcare settings but also in conventional agriculture and farming, multidrug-resistant (MDR) bacterial pathogens are rising worldwide. Given the increasing prevalence of infections caused by MDR bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species (ESKAPE pathogen complex), it is pivotal to explore novel alternative or adjunct treatment options such as phytochemicals with antibiotic properties. Vanillin and vanillin acid represent biologically active ingredients in vanilla that has been known for long for its health-beneficial including antimicrobial effects besides its role as flavoring agent. Therefore, we performed a literature search from the past 10 years summarizing the knowledge regarding the effects of vanilla constituents against bacterial including MDR pathogens. Our survey revealed that vanillin and vanillic acid exerted potent effects directed against distinct Gram-positive and Gram-negative bacteria by inhibiting growth, viability, biofilm formation, quorum sensing and virulence. Remarkably, when combining vanillin or vanillic acid with defined synthetic antibiotics pronounced synergistic effects directed against distinct pathogenic including ESCAPE strains could be observed. In conclusion, vanilla ingredients constitute promising alternative or adjunct options in the combat of infections caused by MDR bacterial pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.