Evidence map›Paper›PMID 36149753›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Monte Carlo Simulation-Guided Design of a Thorium-Based Metal-Organic Framework for Efficient Radiotherapy-Radiodynamic Therapy.

Ziwan Xu, Taokun Luo, Jianming Mao, Caroline McCleary, Eric Yuan, Wenbin Lin

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  8. CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Review
  10. Selenium-Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  11. Article
  12. Article
  13. Selective CONature communications · 2023
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ziwan XuDepartment of Chemistry, The University of Chicago, Chicago, IL-60637, USA.
Taokun LuoDepartment of Chemistry, The University of Chicago, Chicago, IL-60637, USA.
Jianming MaoDepartment of Chemistry, The University of Chicago, Chicago, IL-60637, USA.
Caroline McClearyDepartment of Chemistry, The University of Chicago, Chicago, IL-60637, USA.
Eric YuanDepartment of Chemistry, The University of Chicago, Chicago, IL-60637, USA.
Wenbin LinDepartment of Chemistry, The University of Chicago, Chicago, IL-60637, USA.ORCID 0000-0001-7035-7759
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Nanoscale Metal-organic Frameworks for Light Triggered and X-ray Induced Photodynamic Therapy of Head and Neck CancersU01CA198989 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2015 to 2019
$3.0M
Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersR01CA253655 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2020 to 2024
$2.5M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA253655NCI NIH HHS U01 CA198989
6 · The paper itself

Abstract

High-Z metal-based nanoscale metal-organic frameworks (nMOFs) with photosensitizing ligands can enhance radiation damage to tumors via a unique radiotherapy-radiodynamic therapy (RT-RDT) process. Here we report Monte Carlo (MC) simulation-guided design of a Th-based nMOF built from Th

Indexed as

Colonic NeoplasmsMetal-Organic FrameworksNanostructuresAnimalsLigandsMiceMonte Carlo MethodThoriumLigandsMetal-Organic FrameworksThoriumMetal-Organic FrameworkMonte Carlo SimulationRadiodynamic TherapyRadiotherapy

Identifiers

PMID36149753
PMCPMC9647855
OpenAlexW4296795678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.