ArticleTurkish journal of obstetrics and gynecology2022
Quantitative serum determination of CD3, CD4, CD8, CD16, and CD56 in women with primary infertility: The role of cell-mediated immunity.
Article in Turkish journal of obstetrics and gynecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis.Biomolecules · 2024Pooled it
- Comprehensive analysis of immune-related genes associated with the microenvironment of patients with unexplained infertility.Annals of translational medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Cellular adaptive immunity plays an essential role in the etiology of primary infertility. This study aimed to measure the T-lymphocyte subpopulations and natural killer (NK) cells in infertile women compared with healthy ones. Materials and Methods: From January to September 2021, we conducted this cross-sectional study among women with primary infertility, and healthy women were referred to Isfahan Fertility and Infertility Center affiliated with Najafabad University of medical sciences in Isfahan, Iran for immunological investigations. For each person, we determined quantitative serum measurements of CD3, CD4, CD8, CD4/CD8, CD16, CD56, and CD56+16. Results: This study included one hundred and fifty-one infertile women with a mean age of 31.4±4.7 years and 46 healthy women with a mean age of 31.5±3.4 years. Compared to the controls, immunophenotyping findings in infertile patients revealed a significant drop in CD8 T cells [p=0.01, 95% confidence interval (CI) 0.53 to 4.57] and the percentage of CD 56 NK cells (p=0.005, 95% CI 0.74 to 4.03) in infertile patients. Conclusion: Despite having a normal quantity of CD3 T cells, infertile women had lower CD8 T cells and CD56 NK cells than the controls. More studies are needed to confirm the role of cell-mediated assessments as a screening test in patients with primary infertility.
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