Evidence map›Paper›PMID 36149072›Full record

ArticleRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina)2022

Medicines withdrawn in other countries due to safety concerns: should they continue to be available in the Argentine pharmaceutical market?

Héctor Buschiazzo, Cristian Dorati, Nasim Iusef Venturini, Martín Cañas, Martín Alejandro Urtasun, Gustavo H Marin, Guillermo Rafael Prozzi, Patricia Alejandra Rivadulla, Mariángeles Trionfetti, Perla Mordujovich Buschiazzo

Abstract read
In one paragraph

Article in Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Héctor BuschiazzoCentro Universitario de Farmacología (CUFAR). Facultad de Ciencias Médicas. Universidad Nacional de La Plata. Argentina. Centro colaborador de OMS/OPS. hobuschiazzo@gmail.com.
Cristian DoratiCUFAR. Centro Universitario de Farmacología. Facultad de Ciencias Médicas. UNLP. cristiandorati@yahoo.com.ar.
Nasim Iusef VenturiniCentro Universitario de Farmacología (CUFAR). Facultad de Ciencias Médicas. Universidad Nacional de La Plata. Argentina. Centro colaborador de OMS/OPS. nasim.iusef@gmail.com.
Martín CañasCentro Universitario de Farmacología (CUFAR). Facultad de Ciencias Médicas. Universidad Nacional de La Plata. Argentina. Centro colaborador de OMS/OPS. macanaso@gmail.com.
Martín Alejandro UrtasunCentro Universitario de Farmacología (CUFAR). Facultad de Ciencias Médicas. Universidad Nacional de La Plata. Argentina. Centro colaborador de OMS/OPS. martinurtasun@yahoo.com.ar.
Gustavo H MarinCentro Universitario de Farmacología (CUFAR). Facultad de Ciencias Médicas. Universidad Nacional de La Plata. Argentina. Centro colaborador de OMS/OPS. gmarin2009@gmail.com.
Guillermo Rafael Prozzi. grprozzi@gmail.com.
Patricia Alejandra RivadullaCentro Universitario de Farmacología (CUFAR). Facultad de Ciencias Médicas. Universidad Nacional de La Plata. Argentina. Centro colaborador de OMS/OPS. patricia.rivadulla2012@gmail.com.
Mariángeles Trionfetti. marita.tl@gmail.com.
Perla Mordujovich Buschiazzo. pmordujo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Numerous medicines have been withdrawn from the market because of the risks of serious adverse effects. The objective of this study was to identify in the Argentine pharmaceutical market (APM) the presence of medicines withdrawn in other countries due to safety problems, to analyze the information on their risks and to propose recommendations. Method: observational, descriptive study that explored the presence in the APM, until May 2021, of 462 medicines withdrawn in other countries. Those medicines on this list that are present in the APM and that are not currently authorized in countries with high sanitary surveillance were studied. Results: 17 medicines are still present in the APM, one over-the-counter. The package insert for 11 of the 17 medicines does not mention the adverse effects that led to their withdrawal. It was considered that the permanence in the APM of 16 of them should be reassessed. Conclusions: recommendations are made on actions to be taken by the regulatory authorities with the 17 medicines already present in the APM.

Indexed as

Drug-Related Side Effects and Adverse ReactionsSafety-Based Drug WithdrawalsHumansPharmaceutical PreparationsProduct Surveillance, PostmarketingPharmaceutical Preparationsdrug-related side effects and adverse reactionsproduct surveillance postmarketingsafety-based drug withdrawals

Identifiers

PMID36149072
PMCPMC9590832

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.