ArticleeLife2022
Non-rapid eye movement sleep determines resilience to social stress.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Distinct EEG Features and Sleep/Wake Behaviour Predict Anxiety Phenotypes in Mice.Journal of sleep research · 2026Article
- Sleep quality and psychological resilience: a cross-sectional study of community-dwelling adults in China.BMJ open · 2026Article
- Behavioral phenotype analysis highlights sleep heterogeneity and brain cellular activations in a mouse model of PTSD.Neurobiology of stress · 2026Article
- Time-Dynamic analysis of sex-specific NREM sleep disturbance induced by social isolation among adolescent mice.Translational psychiatry · 2026Article
- Sleep patterns predicting stress resilience are dependent on sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress.Translational psychiatry · 2025Article
- Relationship between neuropsychiatric symptoms and social support in older adults with mild behavioral impairment: a moderated mediation model.Scientific reports · 2025Article
- SleepInvestigatoR: a flexible R function for analyzing scored sleep in rodents.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Exploring students' study time, sleep duration, and perceptions of course difficulty on final examination results: A cross-sectional study.The Journal of chiropractic education · 2025Article
- Association between sleep disorder and anhedonia in adolescence with major depressive disorder: the mediating effect of stress.BMC psychiatry · 2024Article
- Nighttime-specific differential gene expression in suprachiasmatic nucleus and habenula is associated with resilience to chronic social stress.Translational psychiatry · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Article
- Exploring non-rapid eye movement sleep substages in rats to develop biomarkers for depression.Sleep · 2023Article
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- Activation of ventral tegmental area vesicular GABA transporter (Vgat) neurons alleviates social defeat stress-induced anxiety in APP/PS1 mice.Frontiers in aging neuroscience · 2023Article
- Article
- Associations of psychological resilience with macro- and microstructures in NREM and REM sleep in adolescents.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep disorders, often within the same individual. Despite extensive research into the brain mechanisms causing maladaptive behavioral-responses to stress, it is not clear why some individuals exhibit resilience. To examine if sleep has a determinative role in maladaptive behavioral-response to social stress, we investigated individual variations in resilience using a social-defeat model for male mice. Our results reveal a direct, causal relationship between sleep amount and resilience-demonstrating that sleep increases after social-defeat stress only occur in resilient mice. Further, we found that within the prefrontal cortex, a regulator of maladaptive responses to stress, pre-existing differences in sleep regulation predict resilience. Overall, these results demonstrate that increased NREM sleep, mediated cortically, is an active response to social-defeat stress that plays a determinative role in promoting resilience. They also show that differences in resilience are strongly correlated with inter-individual variability in sleep regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.