ArticleEnvironmental toxicology and chemistry2022
Acute Toxicity Testing of the Tire Rubber-Derived Chemical 6PPD-quinone on Atlantic Salmon (Salmo salar) and Brown Trout (Salmo trutta).
Article in Environmental toxicology and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 83 citations in OpenAlex.
- 6PPD and 6PPD-Q Induce Mitochondrial Dysfunction inInternational journal of molecular sciences · 2026Article
- What evidence exists on the environmental occurrence and toxic effects of the tire additive 6PPD: a systematic map protocol.Environmental evidence · 2026Article
- Time Course of Effects and Tissue Concentrations of 6PPDQ in Three Sensitive Salmonids with Additional Data for Two Centrarchid Species.Environmental science & technology · 2026Article
- About the Variability of Tire and Road Wear Marker Components in Air: From Emissions to Atmospheric Deposition.Environmental science & technology · 2026Article
- Metabolic disruption in salmonids following co-exposure to road runoff contaminants 6PPD-Quinone and 9,10-anthraquinone.The Science of the total environment · 2026Article
- Comprehensive review on environmental pollution caused by 6PPD-quinone and remediation strategies.RSC advances · 2026Review
- Review
- Development and application of a simple formate-buffered extraction method for the analysis of 104 organic pollutants in river suspended particulate matter by HPLC-ESI-MS/MS.Analytical and bioanalytical chemistry · 2025Article
- Toxicity of ubiquitous tire rubber antiozonantBiochemistry and biophysics reports · 2025Article
- A Review ofToxics · 2024Article
- Tire-Derived Transformation Product 6PPD-Quinone Induces Mortality and Transcriptionally Disrupts Vascular Permeability Pathways in Developing Coho Salmon.Environmental science & technology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent identification of 6PPD-quinone as the chemical causing acute toxicity in coho salmon has led to substantial concern regarding the toxicity of this contaminant for other aquatic species. Environmental occurrence of 6PPD-quinone is probably high, because it is an oxidation product of a common tire rubber additive. Research on 6PPD-quinone toxicity in fish has revealed a rather unusual pattern, with closely related species exhibiting responses ranging from extreme sensitivity to no effect. Of 11 previously studied fish species, 6PPD-quinone was toxic to four. The species-specific toxicity of 6PPD-quinone complicates urgently needed environmental risk assessment. We investigated the acute toxicity of 6PPD-quinone in Atlantic salmon and brown trout alevins (sac fry). These species have previously not been tested for sensitivity to 6PPD-quinone. The fish were exposed in static conditions in eight treatments with initial concentrations ranging from 0.095 to 12.16 µg/L. Fish were observed for 48 h, and changes in concentrations of 6PPD-quinone were monitored throughout the experiment. No mortalities or substantial changes in behavior were recorded in either Atlantic salmon or brown trout. This provides an important first step in assessing effects of 6PPD-quinone on these economically and culturally highly important species. Environ Toxicol Chem 2022;41:3041-3045. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.