Evidence map›Paper›PMID 36148781›Full record

ArticleCancer medicine2023

Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition.

Julie A Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjønneland, Rudolf Kaaks, Verena Katzke, Matthias B Schulze, Valeria Pala, Carlotta Sacerdote and 15 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Awareness and usage of a dietary guide by cancer patients and clinicians: a national survey study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 8 countries.

Julie A SchmidtCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-7733-8750
Inge HuybrechtsInternational Agency for Research on Cancer, Lyon, France.
Kim OvervadDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Anne Kirstine EriksenDanish Cancer Society Research Center, Copenhagen, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Verena KatzkeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Valeria PalaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Carlotta SacerdoteUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy.
Rosario TuminoHyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy.
Bas Bueno-de-MesquitaFormer senior scientist, Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Maria-Jose SánchezEscuela Andaluza de Salud Pública (EASP), Granada, Spain.
José M HuertaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID 0000-0002-9637-3869
Aurelio BarricarteInstituto de Salud Pública de Navarra, Pamplona, Spain.
Pilar AmianoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Antonio AgudoUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Spain.
Anders BjartellDepartment of Translational Medicine, Medical Faculty, Lund University, Malmö, Sweden.
Tanja StocksDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0002-0904-0557
Elin ThysellDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Maria WennbergDepartment of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden.
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0003-2237-0128
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-5652-356X
University of Oxford · GBCentre international de recherche sur le cancer · FRLund University · SEUmeå University · SEAarhus University · DKAarhus University Hospital · DKAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITBasque Government · ESBellvitge University Hospital · ESDanish Cancer Society · DKFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Cancer Research Center · DEGerman Institute of Human Nutrition · DEInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ESItalian Association for Cancer Research · ITNational Institute for Public Health and the Environment · NLUniversidad de Granada · ESUniversity of Copenhagen · DKUniversity of Potsdam · DE

Funding

Cancer Research UK 29017Cancer Research UK C8221/A29017Medical Research Council MR/M012190/1World Health Organization 001
6 · The paper itself

Abstract

backgroundThe association between protein intake and prostate cancer risk remains unclear.

aimsTo prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality.

methodsIn 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsDuring a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HR DISCUSSION: Considering the weak associations and many tests, the results must be interpreted with caution.

conclusionThis study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.

Indexed as

DietProstatic NeoplasmsAmino AcidsHumansMaleProspective StudiesRisk FactorsAmino Acidsdietary amino acid intakesdietary protein intakesprostate cancer incidenceprostate cancer mortalitytumour subtypes

Identifiers

PMID36148781
PMCPMC9972153
OpenAlexW4296800992

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.