Evidence map›Paper›PMID 36148780›Full record

ArticlePerfusion2023

The effect of relative cerebral hyperperfusion during cardiac surgery with cardiopulmonary bypass to delayed neurocognitive recovery.

Greta Kasputytė, Rasa Bukauskienė, Edmundas Širvinskas, Ilona Razlevičė, Tomas Bukauskas, Tadas Lenkutis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Perfusion, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Greta KasputytėInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID 0000-0002-5790-8955
Rasa BukauskienėDepartment of Cardiac, Thoracic and Vascular Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID 0000-0002-4485-0141
Edmundas ŠirvinskasInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ilona RazlevičėDepartment of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID 0000-0003-0474-9169
Tomas BukauskasDepartment of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID 0000-0002-2326-9593
Tadas LenkutisDepartment of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDelayed neurocognitive recovery (dNCR) remains a common complication after surgery and the incidence of it is determined 30-80% after cardiac surgery with cardiac bypass (CPB) in eldery patients. Many researchers have identified that neuropsychological complications emerge from insufficient cerebral perfusion. Relative cerebral hyperperfusion also disrupts cerebral autoregulation and might play a significant role in dNCR development. The aim of this study is to determine hyperperfusion in the middle cerebral artery during CPB influence to dNCR development and brain biomarker glial fibrillary acidic protein (GFAP) impact in diagnosing dNCR. DESIGNS AND

methodsThis prospective - case control study included patients undergoing elective coronary artery bypass grafting or/and valve surgery with CPB. For cognitive evaluation 101 patients completed Addenbrooke's cognitive examination - ACE-III. To determine mild cognitive dysfunction, cut - off 88 was chosen. Mean BFV was monitored with transcranial Doppler ultrasonography (TCD) and performed before surgery, after induction of anaesthesia, during CPB and after surgery. Preoperative BFV was converted to 100% and used as a baseline. The percentage change of cerebral blood flow velocity during CPB was calculated from baseline. Patients with decreased blood flow velocity were included for further investigation. To measure glial fibrillary acidic protein, blood samples were collected after anaesthesia induction, 24 and 48 h after the surgery. According to the ACE-III test results, patients with relative hyperperfusion were divided into two groups: with Delayed neurocognitive recovery and without dNCR (non-dNCR group).

results101 patients were examined, 67 (69.1%) men and 29 (29.9%) women, age 67.9 (SD 9.2) Increased percentage of BFV was determined for 40 (39.60%) patients. There were no differences in sex, haematocrit, paCO

conclusionsRelative hyperperfusion during CPB may cause dNCR. Elderly patients are sensitive to blood flow velocity acceleration during CPB. GFAP concentration increased 48 h after surgery in dNCR group but did not have any connection with risk factors.

Indexed as

Cardiac Surgical ProceduresCardiopulmonary BypassAgedCase-Control StudiesCerebrovascular CirculationFemaleGlial Fibrillary Acidic ProteinHumansMaleProspective StudiesGlial Fibrillary Acidic Proteinaddenbrooke’s cognitive examinationbrain biomarkercardiac surgerycardiopulmonary bypasscerebral blood flow velocitydelayed neurocognitive recoveryGFAPmiddle cerebral arteryrelative hyperperfusiontranscranial doppler ultrasonography

Identifiers

PMID36148780
PMCPMC10612375
OpenAlexW4296808017

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.