Evidence map›Paper›PMID 36148581›Full record

ArticleAdvanced healthcare materials2022

Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration.

Dax Calder, Ali Fathi, Farshad Oveissi, Simin Maleknia, Terence Abrams, Yiwei Wang, Joanneke Maitz, Kevin Hung-Yueh Tsai, Peter Maitz, Wojtek Chrzanowski and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 2 countries.

Dax CalderSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.
Ali FathiSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-9985-8992
Farshad OveissiSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-7464-8251
Simin MalekniaTetratherix, Sydney, NSW, 2015, Australia.
Terence AbramsTetratherix, Sydney, NSW, 2015, Australia.
Yiwei WangBurns and Reconstructive Surgery Research Group, ANZAC Research Institute, Concord, NSW, 2139, Australia.
Joanneke MaitzBurns and Reconstructive Surgery Research Group, ANZAC Research Institute, Concord, NSW, 2139, Australia.
Kevin Hung-Yueh TsaiBurns and Reconstructive Surgery Research Group, ANZAC Research Institute, Concord, NSW, 2139, Australia.
Peter MaitzBurns and Reconstructive Surgery Research Group, ANZAC Research Institute, Concord, NSW, 2139, Australia.
Wojtek ChrzanowskiFaculty of Medicine and Health, Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
Ivan CanoyAnatomical Pathology, NSW Health Pathology, Concord Repatriation General Hospital, Concord, NSW, 2139, Australia.
Vivek Ashoka MenonAnatomical Pathology, NSW Health Pathology, Concord Repatriation General Hospital, Concord, NSW, 2139, Australia.
Kenneth LeeAnatomical Pathology, NSW Health Pathology, Concord Repatriation General Hospital, Concord, NSW, 2139, Australia.
Benjamin J AhernSchool of Veterinary Science, The University of Queensland, Brisbane, QLD, 4072, Australia.
Natasha E LeanSchool of Veterinary Science, The University of Queensland, Brisbane, QLD, 4072, Australia.
Dina M SilvaMacquarie Medical School, Faculty of Medicine and Health, Macquarie University & Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, 2037, Australia.
Paul M YoungMacquarie Medical School, Faculty of Medicine and Health, Macquarie University & Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, 2037, Australia.
Daniela TrainiMacquarie Medical School, Faculty of Medicine and Health, Macquarie University & Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, 2037, Australia.
Hui Xin OngMacquarie Medical School, Faculty of Medicine and Health, Macquarie University & Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, 2037, Australia.
Rasoul Seyed MahmoudTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
Hossein MontazerianTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
Ali KhademhosseiniTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
Fariba DehghaniSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.
The University of Sydney · AUAnzac Research Institute · AUConcord Repatriation General Hospital · AUSydney Water · AUTerasaki Foundation · USThe University of Queensland · AUCalifornia NanoSystems Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable hydrogels can support the body's innate healing capability by providing a temporary matrix for host cell ingrowth and neovascularization. The clinical adoption of current injectable systems remains low due to their cumbersome preparation requirements, device malfunction, product dislodgment during administration, and uncontrolled biological responses at the treatment site. To address these challenges, a fully synthetic and ready-to-use injectable biomaterial is engineered that forms an adhesive hydrogel that remains at the administration site regardless of defect anatomy. The product elicits a negligible local inflammatory response and fully resorbs into nontoxic components with minimal impact on internal organs. Preclinical animal studies confirm that the engineered hydrogel upregulates the regeneration of both soft and hard tissues by providing a temporary matrix to support host cell ingrowth and neovascularization. In a pilot clinical trial, the engineered hydrogel is successfully administered to a socket site post tooth extraction and forms adhesive hydrogel that stabilizes blood clot and supports soft and hard tissue regeneration. Accordingly, this injectable hydrogel exhibits high therapeutic potential and can be adopted to address multiple unmet needs in different clinical settings.

Indexed as

HydrogelsHydrogelsinjectable hydrogelplatform technologyregenerative medicine

Identifiers

PMID36148581
PMCPMC11468498
OpenAlexW4296807791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.