ArticleFrontiers in public health2022
Relationships between urinary metals concentrations and cognitive performance among U.S. older people in NHANES 2011-2014.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Cumulative and Interactive Effects of Heavy Metal Mixtures Across Neurodegenerative Diseases: A Comparative Review of Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis and Multiple Sclerosis.Journal of xenobiotics · 2026Review
- Research on the imbalance of metal homeostasis and ferroptosis mechanisms in neurodegenerative diseases.Global medical genetics · 2026Article
- Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index.Brain and behavior · 2026Article
- Effects of an Eight-Week Psychomotor Processing Speed Program on Physical and Cognitive Abilities in Community-Dwelling Older Adults.Perceptual and motor skills · 2026Article
- Effects of single and mixed metal exposure on neurocognitive health and quality of life among adults from Bihar India.Scientific reports · 2026Article
- Article
- Serum Albumin/Globulin Ratio and Cognitive Function in Americans: A Linear Association.Brain and behavior · 2025Article
- Metabolome informs about the chemical exposome and links to brain health.Environment international · 2025Review
- Association of menarche, menopause, and reproductive history with cognitive performance in older US women: a cross-sectional study from NHANES 2011-2014.BMC public health · 2025Article
- Association between tinnitus and cognitive impairment: analysis of National Health and Nutrition Examination Survey 2011:2014.Frontiers in neurology · 2025Article
- A machine learning framework for predicting cognitive impairment in aging populations using urinary metal and demographic data.Frontiers in genetics · 2025Article
- Association between composite dietary antioxidant index and cognitive function impairment in the elderly: evidence from NHANES 2011-2014.Frontiers in neurology · 2025Article
- Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis.JAMA network open · 2024Article
- Article
- Predicting poor performance on cognitive tests among older adults using wearable device data and machine learning: a feasibility study.npj aging · 2024Article
- The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort.The journal of nutrition, health & aging · 2024Article
- Cross-sectional and prospective associations of early childhood circulating metals with early and mid-childhood cognition in the Project Viva cohort.Environmental research · 2024Article
- Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database.Frontiers in public health · 2024Article
- Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression.Frontiers in public health · 2024Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epidemiological evidence on Urine metals and cognitive impairment in older individuals is sparse and limited. The goal of this study was to analyze if there was a link between urinary metal levels and cognitive performance in U.S. people aged 60 and up. Methods: The National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2014 were utilized in this cross-sectional analysis. Memory function was quantified using the following methods: Established Consortium for Word Learning in Alzheimer's Disease (CERAD-WL) (immediate learning and recall and delayed recall), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). An inductively coupled plasma mass spectrometry (ICP-MS) was used to estimate urine metal concentrations. The connection of Urine metals level with cognitive function was investigated employing binary logistic regression and restricted cubic spline models. Results: A total of 840 participants aged 60 years and over were enrolled in this study. After controlling for confounders, the association between cadmium, barium, cobalt, cesium, manganese, and thallium and poor cognitive performance showed significance in multiple logistic regression compared to the lowest quartile of metals. In the DSST test, the weighted multivariate adjusted ORs (95% CI) for cadmium in the highest quartile, barium and cesium in the third quartile were 2.444 (1.310-4.560), 0.412 (0.180-0.942) and 0.440 (0.198-0.979), respectively. There were L-shaped associations between urine cesium, barium, or manganese and low cognitive performance in DSST. Urine lead, molybdenum and uranium did not show any significant relationships with cognitive impairment, respectively, compared to the respective lowest quartile concentrations. Conclusion: The levels of barium (Ba), cobalt (Co), cesium (Cs), manganese (Mn), and thallium (Tl) in urine were found to be negatively related to the prevalence of impaired cognitive performance in our cross-sectional investigation. Higher cadmium (Cd) levels were associated with cognitive impairment.
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