ArticleFrontiers in public health2022
Burden of esophageal cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of Recurrence-Free Survival or Disease-Free Survival as a Potential Surrogate Endpoint for Overall Survival in Esophageal Cancer Trials.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Global burden of esophageal cancer attributable to smoking and alcohol, 1990-2021, with projections to 2040: a population-based analysis of the global burden of disease study 2021.Annals of medicine · 2026Observational
- Biomarkers for oesophageal squamous cell carcinoma and the role of HPV: Multi‑omics approaches and current evidence (Review).International journal of oncology · 2026Review
- Hyperspectral reconstruction of white light endoscopy images for enhanced segmentation of early esophageal lesions in patients.iScience · 2026Article
- Hospital-based patterns of esophageal and gastric cancer cases at a major tertiary referral center in Kabul, Afghanistan: a retrospective case series.BMC cancer · 2026Article
- IGFBP1 is a prognostic biomarker in esophageal carcinoma: mechanistic insights from bioinformatics profiling toFrontiers in immunology · 2026Article
- The Burden of Esophageal Cancer and Its Correlation with Dietary, Metabolic, and Behavioral Risk Factors in 204 Countries and Territories: Results from the Global Burden of Disease Study 2021.Medicina (Kaunas, Lithuania) · 2025Article
- Associations among healthcare insurance, tumor-node-metastasis stage and cancer survival: More to be understood.World journal of gastrointestinal oncology · 2025Article
- Insurance coverage and patient outcomes: Understanding changes in esophageal cancer treatment.World journal of gastrointestinal oncology · 2025Article
- Long-term trends in the clinical management and outcomes of patients with gastroesophageal cancer in Norway.Acta oncologica (Stockholm, Sweden) · 2025Article
- Oesophageal cancer-specific mortality risk and public health insurance: Prospective cohort study from China.World journal of gastrointestinal oncology · 2025Article
- Article
- Regional and gender disparities in tobacco-related esophageal cancer: Insights from the Global Burden of Disease study 1990-2021.Tobacco induced diseases · 2025Article
- Development and external validation of a nomogram for predicting the risk of developing esophageal cancer based on a questionnaire: a multicenter case-control study.Frontiers in oncology · 2025Article
- Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells.Molecular and cellular biochemistry · 2024Article
- Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990-2019: analysis for the global burden of disease study.Frontiers in nutrition · 2024Article
- Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021.Frontiers in oncology · 2024Article
- Disease burden of esophageal cancer attributable to low fruit intake in China and globally from 1990 to 2019.American journal of translational research · 2024Article
- High Incidence of Esophageal Cancer in Women in Eritrea and Its Potential Link to Low Age at Menopause: Evidence from a 10-Year Retrospective Data Analysis.Journal of cancer epidemiology · 2024Article
- Spatiotemporal Patterns of Esophageal Cancer Burden Attributable to Behavioral, Metabolic, and Dietary Risk Factors From 1990 to 2019: Longitudinal Observational Study.JMIR public health and surveillance · 2023Observational
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Esophageal cancer is a global health concern. Regularly updated data about the burden of esophageal cancer are essential for formulating specific public policies. We aimed to estimate the global, regional, and national burden and trends of esophageal cancer and its attributable risk factors from 1990 to 2019, by age, sex and socio-demographic index (SDI). Methods: Data about the incidence, death, disability-adjusted life-years (DALYs), and age-standardized rates were collected from Global Burden of Disease study 2019. Estimated annual percentage changes were used to quantify the temporal trends of age-standardized rates. Moreover, the risk factors attributable to esophageal cancer deaths were also presented. Results: There were 534,563 incident cases and 498,067 deaths in 2019, contributing to 11,666,017 DALYs. The absolute numbers of incidence, death, and DALYs had increased from 1990 to 2019, contrasting with declined changes in their corresponding age-standardized rates. The burden of esophageal cancer varied across different regions and countries, and the age-standardized rates were negative with SDI. Almost half of the esophageal cancer was concentrated in China. Males accounted for most of the burden of esophageal cancer, and the onset age tended to be older. The death of esophageal cancer was primarily attributable to smoking, followed by alcohol use, high body mass index, diet low in fruits and diet low in vegetables. Conclusion: The burden of esophageal cancer was heterogeneous across regions and countries by sex, age, and SDI, providing information for governments that may help to formulate more targeted policies.
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