ArticleFrontiers in physiology2022
Novel strategies to improve chicken performance and welfare by unveiling host-microbiota interactions through hologenomics.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Enterococcus faecalis GP1764 induces an early differential gene expression in the intestine on key pathways related to cellular immune response and gut barrier function in chickens.Poultry science · 2026Article
- BioSamples database: the global hub for sample metadata and multi-omics integration.Nucleic acids research · 2026Article
- Functional gut microbiota dynamics of generalist and specialist bacteria in association with chicken growth.ISME communications · 2026Article
- Effect of probiotic supplementation on productive performance and epithelial intestinal integrity of broiler chickens exposed to heat stress.Tropical animal health and production · 2025Article
- HoloFood Data Portal: holo-omic datasets for analysing host-microbiota interactions in animal production.Database : the journal of biological databases and curation · 2025Article
- FoodMicroDB: A microbiome database for composition and time-series research in food.iMetaOmics · 2024Article
- Diet replacement with whole insect larvae affects intestinal morphology and microbiota of broiler chickens.Scientific reports · 2024Article
- Effect of composite yeast culture on the jejunal barrier function, inflammatory response, and microbial community structure of laying hens during the late stage of egg production.Frontiers in veterinary science · 2024Article
- Influence of the rearing system on the ileum microbiome, metabolome, and transcriptome in meat rabbits.Frontiers in veterinary science · 2024Article
- Impact of feed additives and host-related factors on bacterial metabolites, mucosal integrity and immune response in the ileum of broilers.Veterinary research communications · 2023Article
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12 authors.
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Abstract
Fast optimisation of farming practices is essential to meet environmental sustainability challenges. Hologenomics, the joint study of the genomic features of animals and the microbial communities associated with them, opens new avenues to obtain in-depth knowledge on how host-microbiota interactions affect animal performance and welfare, and in doing so, improve the quality and sustainability of animal production. Here, we introduce the animal trials conducted with broiler chickens in the H2020 project HoloFood, and our strategy to implement hologenomic analyses in light of the initial results, which despite yielding negligible effects of tested feed additives, provide relevant information to understand how host genomic features, microbiota development dynamics and host-microbiota interactions shape animal welfare and performance. We report the most relevant results, propose hypotheses to explain the observed patterns, and outline how these questions will be addressed through the generation and analysis of animal-microbiota multi-omic data during the HoloFood project.
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