Evidence map›Paper›PMID 36148290›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2022

A Comparative Study Between Cytomegalovirus Immunoglobulin M-Positive and CMV Immunoglobulin M-Negative Biliary Atresia in Infants Attending a Tertiary Care Hospital in Bangladesh.

Sharmin Akter, A S M Bazlul Karim, Md Wahiduzzaman Mazumder, Md Rukunuzzaman, Khan Lamia Nahid, Bishnu Pada Dey, Maimuna Sayeed, A Z M Raihanur Rahman, Kaniz Fathema, Mukesh Khadga

Open access · diamondAbstract read
In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sharmin AkterDepartment of Pediatric Gastroenterology & Nutrition, Faculty of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-4804-876X
A S M Bazlul KarimDepartment of Pediatric Gastroenterology & Nutrition, Faculty of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-8899-9052
Md Wahiduzzaman MazumderDepartment of Pediatric Gastroenterology & Nutrition, Faculty of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0001-6947-9572
Md RukunuzzamanDepartment of Pediatric Gastroenterology & Nutrition, Faculty of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-0330-5080
Khan Lamia NahidDepartment of Pediatric Gastroenterology & Nutrition, Faculty of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-0832-550X
Bishnu Pada DeyDepartment of Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-2379-3923
Maimuna SayeedDepartment of Gastroenterology, Evercare Hospital, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-4536-4508
A Z M Raihanur RahmanDepartment of Pediatric Gastroenterology & Nutrition, Faculty of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
Kaniz FathemaDepartment of Paediatric Gastroenterology & Nutrition, Sir Salimullah Medical College, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-2596-9788
Mukesh KhadgaDepartment of Pediatrics, Sumeru Hospital, Dhapakhel, Kathmundu, Nepal.ORCID https://orcid.org/0000-0001-8966-8389
Bangladesh Medical University · BDDhaka Medical College and Hospital · BDSquare Hospitals · BDSukraraj Tropical & Infectious Disease Hospital · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Perinatal cytomegalovirus (CMV) infection can lead to biliary atresia (BA) in different entities. This study aimed to compare the clinical, hematological, biochemical, and histological features of infants with BA based on their CMV immunoglobulin M (IgM) status at presentation. Methods: This cross-sectional descriptive study was carried out between January 2019 and June 2020 at the Department of Pediatric Gastroenterology and Nutrition at the Bangabandhu Sheikh Mujib Medical University (BSMMU) in Dhaka. Forty-three patients with BA were selected purposively and categorized into either the CMV IgM-positive or CMV IgM-negative BA group. Categorical variables were compared using Fisher's exact test and chi-square tests, while the Student's Results: Thirty-three (76.7%) of the cases were between 2 and 3 months of age on admission. The clinical, hematological, and biochemical parameters did not differ significantly between the CMV IgM-positive and CMV IgM-negative BA groups. Most (50.0%) of the CMV IgM-positive cases had fibrosis stage F2, while 43.5% of the CMV IgM-negative cases had fibrosis stage F3, with no significant difference between the groups ( Conclusion: Our data shows no significant distinction between CMV IgM-positive and CMV IgM-negative BA, suggesting that CMV does not contribute to BA pathogenesis.

Indexed as

BangladeshBiliary atresiaCytomegalovirusImmunoglobulin

Identifiers

PMID36148290
PMCPMC9482831
OpenAlexW4295952554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.