ArticlePediatric gastroenterology, hepatology & nutrition2022
Functional Gastrointestinal Disorders in Neonates and Toddlers According to the Rome IV Criteria: A Systematic Review and Meta-Analysis.
Article in Pediatric gastroenterology, hepatology & nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 16 citations in OpenAlex.
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- Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut-Brain Interaction: A Narrative Review.Nutrients · 2026Review
- Beyond the Organic: A Biopsychosocial Analysis of Pediatric Functional Gastrointestinal Disorders-A Retrospective Chart Review.Children (Basel, Switzerland) · 2026Article
- Green Stool Predominance in Babies and Subsequent Bowel Function at 1-2 Years of Age.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Mitochondrial Dysfunction in the Cardiovascular Disease Continuum: Problems of Studying the Progression During the Follow-Up of the Pathologies.International journal of molecular sciences · 2025Review
- Prevalence of Disorders of Gut-Brain Interaction in Indonesian Adolescents: Has It Increased during the Coronavirus Disease Pandemic?Pediatric gastroenterology, hepatology & nutrition · 2025Article
- Somatic symptom severity during acute illnesses among children with functional gastrointestinal disorders.Clinical and experimental pediatrics · 2025Article
- Parents' preferences for herbal supplements in managing functional gastrointestinal disorders.BMC complementary medicine and therapies · 2025Article
- Anxiety and depression in pediatric patients with disorder of brain-gut interaction: the role of diarrhea and abdominal pain as key determinants.Frontiers in pediatrics · 2025Article
- Bowel function in a prospective cohort of 1052 healthy term infants up to 4 months of age.European journal of pediatrics · 2024Article
- [Research status and prospects of probiotics in functional gastrointestinal disorders in infants and toddlers].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Prevalence of functional gastrointestinal disorders in Saudi infants and toddlers: A cross-sectional multicenter study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- [Prevalence of Infant Regurgitation: Experience of the Working Group on Disorders of Gut-Brain Interaction of the Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN)].Acta gastroenterologica LatinoamericanaArticle
- [Prevalence of Infantile Colic: Experience of the Working Group on Disorders of Gut-Brain Axis of the Latin American Society of Paediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN)].Acta gastroenterologica LatinoamericanaArticle
- [Prevalence of Infant Dyschezia: Experience of the Working Group on Disorders of the Gut-Brain Interaction of the Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN)].Acta gastroenterologica LatinoamericanaArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Functional gastrointestinal disorders (FGIDs) are classified as a combination of persistent gastrointestinal symptoms. The Rome IV criteria can elucidate several factors in the pathogenesis of FGIDs. The frequency of FGIDs can differ between clinical and nonclinical settings and between geographic regions. To determine the global prevalence of FGIDs in neonates and toddlers according to the Rome IV criteria. We included cohort and descriptive observational studies reporting the prevalence of FGIDs according to the Rome IV criteria in children aged 0-48 months. We searched the Medline, Embase, Lilacs, and CENTRAL databases from May 2016 to the present day. Furthermore, unpublished literature was searched to supplement this information. The Strengthening the Reporting of Observational Studies in Epidemiology statement was used to evaluate the risk of bias. A meta-analysis of the proportions was performed using MetaProp in R. The results are reported in forest plots. We identified and analyzed 15 studies comprising 48,325 participants. Six studies were conducted in Europe, three in Latin America, two in North America, and four in Asia. Most participants were 12-48 months old (61.0%) and were recruited from the community. The global prevalence of FGIDs was 22.0% (95% confidence interval, 15-31%). The most common disorder was functional constipation (9.0%), followed by infant regurgitation syndrome (8.0%). Its prevalence was higher in the Americas (28.0%). FGIDs, as defined by the Rome IV criteria, are present in 22% of children, and the most common primary disorder is functional constipation. A higher prevalence of FGIDs has been reported in America.
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