Evidence map›Paper›PMID 36147800›Full record

ArticleFrontiers in pediatrics2022

The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease.

Daisuke Shimizu, Takayuki Hoshina, Masaru Kawamura, Yoshie Tomita, Yasufumi Hidaka, Masumi Kojiro, Jun Muneuchi, Junji Kamizono, Kenichiro Yamaguchi, Yoshihisa Fujino and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Daisuke ShimizuDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, Japan.
Takayuki HoshinaDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, Japan.
Masaru KawamuraDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yoshie TomitaDepartment of Pediatrics, Kitakyushu Municipal Yahata Hospital, Kitakyushu, Japan.
Yasufumi HidakaDepartment of Pediatrics, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Masumi KojiroDepartment of Pediatrics, Kitakyushu General Hospital, Kitakyushu, Japan.
Jun MuneuchiDepartment of Pediatrics, Japan Community Health Care Organization Kyushu Hospital, Kitakyushu, Japan.
Junji KamizonoDepartment of Pediatrics, Kitakyushu Municipal Yahata Hospital, Kitakyushu, Japan.
Kenichiro YamaguchiDepartment of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, Japan.
Yoshihisa FujinoDepartment of Environmental Epidemiology, School of Medicine, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, Japan.
Koichi KusuharaDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JPKitakyushu City Yahata Hospital · JPNational Hospital Organization · JPKitakyushu Municipal Medical Center · JPKyushu Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Enterovirus causing hand-foot-mouth disease (HFMD) has been reported to be associated with the development of Kawasaki disease (KD), whereas the involvement of enterovirus in the clinical course of KD is uncertain. The aim of this study is to investigate the association between the clinical course of KD and HFMD epidemics. Methods: This study included 108 patients who developed KD during HFMD epidemic seasons (July and August) from 2010 to 2014 and who were initially treated with high-dose intravenous immunoglobulin (IVIG). A mean of ≥5.0 HFMD patients reported weekly from each sentinel medical facility was considered to represent a large HFMD epidemic. We compared the clinical characteristics of KD patients in summers of years with and without large HFMD epidemics. Results: Large HFMD epidemics occurred in 2011 and 2013. The number of KD patients in summer was the highest in 2011. The proportion of patients with resistance to the IVIG therapy in summers of years with the large epidemics (14%) was significantly lower than that in summers of other years (31%, Conclusion: Patients developing KD during large HFMD epidemic may have good responsiveness to IVIG. It is important to identify microbes from KD patients to predict responsiveness to IVIG therapy.

Indexed as

enterovirus (EV)hand-foot-and-mouth disease (HFMD)Kawasaki disease (KD)negative correlationresponsiveness to immunoglobulin therapy

Identifiers

PMID36147800
PMCPMC9485717
OpenAlexW4294707520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.