Evidence map›Paper›PMID 36147791›Full record

ArticleOrthopaedic journal of sports medicine2022

Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Randomized Controlled Trial.

Michael Baria, Angela Pedroza, Christopher Kaeding, Sushmitha Durgam, Robert Duerr, David Flanigan, James Borchers, Robert Magnussen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04351087 (Microfragmented Adipose Tissue Versus Platelet-rich Plasma for Knee Osteoarthritis), which is not on this map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04351087 nacompletednot on this map

Microfragmented Adipose Tissue Versus Platelet-rich Plasma for Knee Osteoarthritis: a Randomized Comparative Trial

TypeinterventionalSponsorOhio State UniversityRan2020 to 2022Enrolled79ConditionsOsteoarthritis, Knee, Microfragmented Adipose Tissue, Platelet-Rich PlasmaArmsPlatelet Rich Plasma
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Stem cell injections for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2025
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  6. Review
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  10. Adipose-derived and bone marrow aspirate concentrate injections for osteoarthritis: A scoping review.PM & R : the journal of injury, function, and rehabilitation · 2026
    Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael BariaDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, Ohio, USA.
Angela PedrozaSports Medicine Research Institute, The Ohio State University, Columbus, Ohio, USA.
Christopher KaedingDepartment of Orthopaedics, The Ohio State University, Columbus, Ohio, USA.
Sushmitha DurgamDepartment of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
Robert DuerrDepartment of Orthopaedics, The Ohio State University, Columbus, Ohio, USA.
David FlaniganDepartment of Orthopaedics, The Ohio State University, Columbus, Ohio, USA.
James BorchersDepartment of Family and Community Medicine, The Ohio State University, Columbus, Ohio, USA.
Robert MagnussenDepartment of Orthopaedics, The Ohio State University, Columbus, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Platelet-rich plasma (PRP) has been established as safe and effective for knee osteoarthritis (OA). Another orthobiologic therapy, microfragmented adipose tissue (MFAT), has gained attention because of its heterogeneous cell population (including mesenchymal stem cells). However, prospective comparative data on MFAT are lacking. Because of the safety, efficacy, and simplicity of PRP, new therapeutics such as MFAT should be compared directly with PRP. Purpose: To compare patient-reported outcomes of a single injection of PRP versus MFAT for knee OA. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 58 patients with symptomatic knee OA (Kellgren-Lawrence grades 1-4) were randomized to receive a single injection of either leukocyte-rich PRP or MFAT under ultrasound guidance. PRP was created by processing 156 mL of whole blood. MFAT was created by harvesting 30 mL of adipose tissue via standard lipoaspiration. Scores for the Knee injury and Osteoarthritis Outcome Score (KOOS) subscales and visual analog scale for pain with Activities of Daily Living (VAS-ADL) were recorded at baseline and at 1, 3, and 6 months after the injection. The primary outcome was the KOOS-Pain subscore at 6 months after the injection. Results: The PRP group (n = 30) had a mean volume of 5.12 ± 1.12 mL injected. This consisted of a mean platelet count of 2673.72 ± 1139.04 × 10 Conclusion: A single injection of either PRP or MFAT resulted in a clinically meaningful improvement for patients with knee OA at 6 months, with no difference between treatment groups. Registration: NCT04351087 (ClinicalTrials.gov identifier).

Indexed as

knee osteoarthritismesenchymal stem cellmicrofragmented adipose tissueplatelet-rich plasma

Identifiers

PMID36147791
PMCPMC9486262

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.