ArticleNature aging2022
Characterization of cellular senescence in aging skeletal muscle.
Open access · greenAbstract read
In one paragraph
Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 1 pooled it
19.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
157 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.Aging and disease · 2025Pooled it
- Trial
- The nucleus as a mechanobiological hub in muscle aging.Nucleus (Austin, Tex.) · 2026Review
- 4-Octyl Itaconate Attenuates Age-Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Review
- A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions.Ageing research reviews · 2026Review
- Metabolic Vulnerability and Regenerative Failure of the External Urethral Sphincter: A Ferroptosis-Associated Framework for Stress Urinary Incontinence.Biomolecules · 2026Review
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Treating age-related loss of muscle mass and function: Where should we be focusing?The Journal of physiology · 2026Review
- Phase-transition failure in aged skeletal muscle regeneration.Biogerontology · 2026Review
- State-Dependent FGF Signaling in Satellite Cell-Mediated Skeletal Muscle Regeneration and Pathological Remodeling.Biomolecules · 2026Review
- Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline.iScience · 2026Article
- Restoration of circadian rhythm as novel targets against sarcopenia.Chinese medical journal · 2026Review
- Article
- The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise.Journal of cellular physiology · 2026Review
- Muscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.GeroScience · 2026Article
- A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging.Science advances · 2026Article
- LaminA/C-dependent cellular senescence signaling promotes skeletal muscle atrophy and abnormalities in Parkinson's disease.Cell death & disease · 2026Article
- Fibro-Adipogenic Progenitor Cell Alterations in Skeletal Muscle: Pathological Dysfunction or Adaptive Reprogramming?International journal of molecular sciences · 2026Review
- Multicellular senescence impairs skeletal muscle recovery following disuse in aging.Science advances · 2026Article
97 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
24 authors at 7 institutions in 2 countries.
Xu ZhangRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Leena HabiballaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Zaira AversaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Yan Er NgRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Ayumi E SakamotoRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Davis A EnglundRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Vesselina M PearsallRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Thomas A WhiteRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Matthew M RobinsonSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Donato A RivasNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts, USA.
Surendra DasariDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Adam J HrubyRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Anthony B LagnadoRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Sarah K JachimMayo clinic graduate school of biomedical science, rochester, MN, USA.
Antoneta GranicNIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Avan A SayerNIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Diana JurkRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Ian R LanzaDivision of Endocrinology, Mayo Clinic, Rochester, MN, USA.
Sundeep KhoslaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts, USA.
K Sreekumaran NairDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.
Marissa J SchaferRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
João F PassosRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Florida · USMayo Clinic · USMayo Clinic in Arizona · USNIHR Newcastle Biomedical Research Centre · GBTufts University · USOregon State University · USZero to Three · US
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla · 2019 to 2026
$28.7MTUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ravi Jasuja · 2008 to 2026
$23.9MPILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2MMusculoskeletal Research Training ProgramT32AR056950 · NIAMS · MAYO CLINIC ROCHESTER · PI Jennifer J Westendorf · 2009 to 2026
$7.0MSenescence and Growth Differentiation Factors as Modifiers of AgingR01AG055529 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K · 2018 to 2022
$3.1MThe role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUH3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.6MPostdoctoral Training Program for Research on AgingT32AG049672 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2016 to 2022
$1.3MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUG3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2021 to 2022
$1.1MSenescent Vascular Cells as Mediators of Cognitive DeclineR00AG058798 · NIA · MAYO CLINIC ROCHESTER · PI SCHAFER, MARISSA JOY · 2021 to 2023
$747kPhenotypes of Aging & SenescenceR56AG060907 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, LEBRASSEUR, NATHAN K · 2018 to 2018
$684kSenescent Vascular Cells as Mediators of Cognitive DeclineK99AG058798 · NIA · MAYO CLINIC ROCHESTER · PI SCHAFER, MARISSA JOY · 2019 to 2020
$249kDepartment of HealthNCI NIH HHS UG3 CA268103NCI NIH HHS UH3 CA268103NIAMS NIH HHS T32 AR056950NIA NIH HHS K99 AG058798NIA NIH HHS P01 AG062413NIA NIH HHS P30 AG031679NIA NIH HHS R00 AG058798NIA NIH HHS R01 AG055529NIA NIH HHS R01 AG068048NIA NIH HHS R56 AG060907NIA NIH HHS T32 AG049672NIDDK NIH HHS P30 DK084567
Abstract
Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are prone to senesce has not been methodically examined. Herein, using single cell and bulk RNA-sequencing and complementary imaging methods on SkM of young and old mice, we demonstrate that a subpopulation of old fibroadipogenic progenitors highly expresses
Indexed as
AgingCellular SenescenceAnimalsCyclin-Dependent Kinase Inhibitor p16HumansMiceMuscle, SkeletalPhenotypeCyclin-Dependent Kinase Inhibitor p16
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.