Evidence map›Paper›PMID 36147762›Full record

ArticleThe Neurohospitalist2022

Intrathecal Methotrexate Toxicity Resulting in Brain Death due to Generalized Cerebral Edema Case Report.

Haoming Pang, Julie L Chan, Serguei I Bannykh, Michael Gezalian, Shouri Lahiri, Shahed Toossi, Maranatha Ayodele

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Neurohospitalist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haoming PangDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-0553-6720
Julie L ChanDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-0782-6548
Serguei I BannykhDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Michael GezalianDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shouri LahiriDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shahed ToossiDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Maranatha AyodeleDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrathecal methotrexate (IT MTX) resulting in severe adverse events including life-threatening cerebral edema is not well described. We report a rare case of death in a 37-year-old BRCA1+ woman with metastatic triple-negative breast cancer status post mastectomy following administration of IT MTX for leptomeningeal carcinomatosis. Within the 24 hours after intraoperative IT MTX delivery, she developed neurologically devastating diffuse cerebral edema leading to uncal and cerebellar tonsillar herniation. This case report highlights a rare but devastating side effect of IT MTX.

Indexed as

breast cancercarcinomatosiscase reportcerebral edemaintrathecal methotrexate

Identifiers

PMID36147762
PMCPMC9485701
OpenAlexW4281698566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.