Evidence map›Paper›PMID 36147701›Full record

ReviewFrontiers in aging neuroscience2022

The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer's disease: A systemic review and meta-analysis.

Zhenyu Wei, Jiaqi Fu, Huazheng Liang, Mingli Liu, Xiaofei Ye, Ping Zhong

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07316413 (Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration), which is not on this map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07316413 narecruitingnot on this mapstarted 2025, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration

TypeinterventionalSponsorUniversità degli Studi di BresciaRan2025 to 2029Enrolled120ConditionsFTLD, FTD, bvFTD, PPAArmsTheta burst stimulation, Sham Theta burst stimulation
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  7. Neuroscientific therapies for subjective tinnitus.Journal of Zhejiang University. Science. B · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhenyu WeiDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Jiaqi FuSchool of Health Science and Engineering, Shanghai University of Science and Technology, Shanghai, China.
Huazheng LiangClinical Research Center for Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Mingli LiuDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Xiaofei YeDepartment of Statistics, Naval Medical University, Shanghai, China.
Ping ZhongDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Shanghai University of Engineering Science · CNUniversity of Shanghai for Science and Technology · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer's Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients. Methods: We systematically searched relevant literatures in four major databases - PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials [Central] before 28 Results: A total of 14 studies involving 513 AD patients were finally included for meta-analysis. It was found that rTMS significantly improved global cognitive function (SMD = 0.24, 95%CI, 0.12 to 0.36, Conclusion: rTMS can improve the global cognition and daily living ability of AD patients. In addition, attention should be paid to the safety of rTMS in AD patients with seizures. Given the relatively small sample size, our results should be interpreted with caution.

Indexed as

activities of daily livingAlzheimer’s diseasecognitive functionrepetitive transcranial magnetic stimulationtherapeutic efficacy

Identifiers

PMID36147701
PMCPMC9485622
OpenAlexW4294752456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.