Evidence map›Paper›PMID 36147596›Full record

ArticleOpen forum infectious diseases2022

Meta-Analysis: Outcomes of Surgical and Medical Management of Diabetic Foot Osteomyelitis.

David H Truong, Roger Bedimo, Matthew Malone, Dane K Wukich, Orhan K Oz, Amanda L Killeen, Lawrence A Lavery

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
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  11. Inflammation, diabetic foot and related treatments.Frontiers in endocrinology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Evaluation and Management of Diabetes-related Foot Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David H TruongSurgical Service, Podiatry Section, Veterans Affairs North Texas Health Care System, Dallas, Texas, USA.ORCID https://orcid.org/0000-0003-2688-066X
Roger BedimoMedical Service, Infectious Disease Section, Veterans Affairs North Texas Health Care System, Dallas, Texas, USA.
Matthew MaloneInfectious Disease and Microbiology, School of Medicine, Western Sydney University, Campbelltown, Australia.
Dane K WukichDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Orhan K OzDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Amanda L KilleenDepartment of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Lawrence A LaveryDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study was to evaluate clinical outcomes in the published literature on medical and surgical management of diabetic foot osteomyelitis (DFO). Methods: A PubMed and Google Scholar search of articles relating to DFO was performed over the dates of January 1931 to January 2020. Articles that involved Charcot arthropathy, case reports, small case series, review articles, commentaries, nonhuman studies, and non-English articles were excluded. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was used to rate the bias of each study. A meta-analysis was performed using random-effects and inverse variance methods. The search yielded 1192 articles. After review and the removal of articles that did not meet inclusion criteria, 28 articles remained. Eighteen articles were related to the medical management of DFO and 13 articles were related to surgical management. Three articles looked at a combination of medical and surgical management and were included in both groups. Heterogeneity was evaluated using Cochran Q, Results: The average success rate was 68.2% (range, 17.0%-97.3%) for medical treatment and 85.7% (range, 65.0%-98.8%) for surgical and medical treatment. There were significant inconsistencies in accounting for peripheral arterial disease and peripheral neuropathy. There was significant heterogeneity in outcomes between studies. However, there was a high rate of successful treatment and a wide range between patients with medical treatment and combined surgical and medical treatment. Conclusions: Additional properly designed prospective studies with gold-standard references for diagnosing osteomyelitis are needed to help determine whether medical management of DFO can be successful without surgical intervention.

Indexed as

antibioticsdiabetesdiabetic foot infectionosteomyelitissurgical treatment

Identifiers

PMID36147596
PMCPMC9487605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.