Evidence map›Paper›PMID 36147579›Full record

ArticleFrontiers in endocrinology2022

Diagnostic performance of C-TIRADS combined with SWE for the diagnosis of thyroid nodules.

Xiao-Qiang Gao, Yue Ma, Xiao-Shan Peng, Ling-Ling Wang, Hai-Xia Li, Xiu-Lan Zheng, Ying Liu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Predictive value of real-time shear wave elastography combined with serum thyroglobulin in thyroid cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiao-Qiang GaoDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Yue MaDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Xiao-Shan PengDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Ling-Ling WangDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Hai-Xia LiDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Xiu-Lan ZhengDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Ying LiuDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Harbin Medical University · CNThird Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the value of the optimal parameters of shear wave elastography (SWE) to enhance the identification of benign and malignant thyroid nodules by C-TIRADS. Methods: The two-dimensional ultrasonography images and SWE images of 515 patients with a total of 586 thyroid nodules were retrospectively analyzed. The nodules were divided into the D ≤10 mm and D >10 mm groups according to size and were graded by C-TIRADS. With the pathological results as the gold standard, the receiver operating characteristic (ROC) curves were drawn, and the area under the curve (AUC) was calculated to compare the diagnostic performances of C-TIRADS, SWE, and the combination of the two on the benign and malignant thyroid nodules. Results: The ROC showed that the AUC of the maximum elastic modulus (0.875) was higher than that of the mean elastic modulus (0.798) and elasticity ratio (0.772), with an optimal cutoff point of 51 kPa, which was the optimal parameter to distinguish the malignant from the benign nodules ( Conclusion: The diagnostic performance of SWE in combination with TIRADS was better than that of SWE or C-TIRADS alone. Here, SWE enhanced the diagnostic performance of C-TIRADS for the benign and malignant thyroid nodules, most significantly for nodules with D ≤10 mm.

Indexed as

Elasticity Imaging TechniquesThyroid NoduleHumansRetrospective StudiesROC CurveUltrasonographyfine-needle aspiration biopsyshear wave elastographythyroid imaging reporting and data systemthyroid nodulesTIRADSultrasonography

Identifiers

PMID36147579
PMCPMC9486702
OpenAlexW4294740805

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.