Evidence map›Paper›PMID 36147526›Full record

ReviewFrontiers in bioengineering and biotechnology2022

Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy.

Zhihong Cheng, Yongshuang Li, Duoyi Zhao, Wei Zhao, Meng Wu, Weilin Zhang, Yan Cui, Peng Zhang, Zhiyu Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

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  7. The Role of Adenosine in Overcoming Resistance in Sarcomas.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Zhihong ChengDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Yongshuang LiDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Duoyi ZhaoDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Wei ZhaoDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Meng WuDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Weilin ZhangDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Yan CuiDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Peng ZhangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Zhiyu ZhangDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Fourth Affiliated Hospital of China Medical University · CNChina Medical University · CNChangchun Institute of Applied Chemistry · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past few decades, the combination of proteins and small-molecule drugs has made tremendous progress in cancer treatment, but it is still not satisfactory. Because there are great differences in molecular weight, water solubility, stability, pharmacokinetics, biodistribution, and the ways of release and action between macromolecular proteins and small-molecule drugs. To improve the efficacy and safety of tumor treatment, people are committed to developing protein and drug co-delivery systems. Currently, intracellular co-delivery systems have been developed that integrate proteins and small-molecule drugs into one nanocarrier

Indexed as

cancer therapyintracellular co-deliverynanocarriersproteinssmall-molecule drugs

Identifiers

PMID36147526
PMCPMC9485877
OpenAlexW4294723689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.