Evidence map›Paper›PMID 36147517›Full record

ArticleJournal of drug and alcohol research2012

Chronic Methamphetamine Causes Differential Expression of Immediate Early Genes in the Nucleus Accumbens and Midbrain of Rats.

Tiffany Garrett, Ingrid Tulloch, Michael T McCoy, Bruce Ladenheim, Subramaniam Jayanthi, Irina Krasnova, Genevieve Beauvais, Amber Hodges, Carolyn Davis, Jean Lud Cadet

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug and alcohol research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tiffany GarrettMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Ingrid TullochMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Michael T McCoyMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Bruce LadenheimMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Subramaniam JayanthiMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Irina KrasnovaMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Genevieve BeauvaisMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Amber HodgesMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Carolyn DavisMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Jean Lud CadetMolecular Neuropsychiatry Branch, DHHS/NIH/NIDA-Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA.
National Institute on Drug Abuse · US

Funding

Neurotoxicity in the adult rat following chronic exposure to methamphetamineZIADA000552 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI CADET, JEAN LUD · 2009 to 2025
$34.3M
Intramural NIH HHS ZIA DA000552
6 · The paper itself

Abstract

The present study investigated whether chronic methamphetamine (METH) would suppress METH-induced mRNA expression of immediate early genes (IEGs) in the rat brain. Rats were given METH or saline over two weeks. After an overnight withdrawal, saline- and METH-pretreated rats received an acute saline or METH challenge. The acute METH challenge increased expression of members of activator protein 1 (AP-1) and Nr4a IEG families in the nucleus accumbens (NAc) and midbrain of saline-pretreated rats. Chronic METH exposure attenuated the effects of acute METH challenge on AP-1 IEG expression in the NAc. However, chronic METH failed to attenuate acute METH-induced increases of Nr4a1 and Nr4a3 expression in the NAc. In contrast to observations in the NAc, chronic METH did not prevent acute METH-induced changes in IEG expression in the midbrain. These results suggest that these two brain regions that are implicated in neuroplastic effects of illicit substances might be differentially affected by psychostimulants.

Indexed as

c-fosc-jundopaminefosBmidbrainnucleus accumbensNurr77

Identifiers

PMID36147517
PMCPMC9491698
OpenAlexW2124997510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.