Evidence map›Paper›PMID 36147453›Full record

ArticleBrain communications2022

Natural course of visual snow syndrome: a long-term follow-up study.

Michael Graber, Adrian Scutelnic, Antonia Klein, Francesca Puledda, Peter J Goadsby, Christoph J Schankin

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Repetitive transcranial magnetic stimulation for visual snow syndrome: symptoms relief and changes in brain dynamics. A case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  5. Visual Snow Syndrome: Therapeutic Implications.Journal of clinical medicine · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Visual Disturbances Spectrum in Pediatric Migraine.Journal of clinical medicine · 2023
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Michael GraberDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.
Adrian ScutelnicDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.ORCID https://orcid.org/0000-0001-9053-584X
Antonia KleinDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.
Francesca PuleddaHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London SE1 1YR, London, UK.ORCID https://orcid.org/0000-0002-1933-4049
Peter J GoadsbyHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London SE1 1YR, London, UK.ORCID https://orcid.org/0000-0003-3260-5904
Christoph J SchankinDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.ORCID https://orcid.org/0000-0003-4668-6098
University of Bern · CHKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visual snow syndrome is characterized by a continuous visual disturbance resembling a badly tuned analogue television and additional visual and non-visual symptoms causing significant disability. The natural course of visual snow syndrome has not hitherto been studied. In this prospective longitudinal study, 78 patients with the diagnosis of visual snow syndrome made in 2011 were re-contacted in 2019 to assess symptom evolution using a semi-structured questionnaire. Forty patients (51% of 78) were interviewed after 84 ± 5 months (mean ± SD). In all patients, symptoms had persisted. Visual snow itself was less frequently rated as the most disturbing symptom (72 versus 42%, P = 0.007), whereas a higher proportion of patients suffered primarily from entopic phenomena (2 versus 17%, P = 0.024). New treatment was commenced in 14 (35%) patients, of whom in seven, visual snow syndrome was ameliorated somewhat. Three (7%) experienced new visual migraine aura without headache, and one (2%) had new migraine headache. There were no differences in the levels of anxiety and depression measured by the Patient Health Questionnaire 8 and the Generalized Anxiety Disorder Scale 7. Thirty-eight patients (49%) were lost to follow-up. In visual snow syndrome, symptoms can persist over 8 years without spontaneous resolution, although visual snow itself might become less bothersome.

Indexed as

aurafollow-upmigrainenatural coursevisual snow

Identifiers

PMID36147453
PMCPMC9487631
OpenAlexW4295224462

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.