Evidence map›Paper›PMID 36147357›Full record

ArticleFrontiers in pharmacology2022

Rechallenge of immunotherapy beyond progression in patients with extensive-stage small-cell lung cancer.

Lingling Li, Tingting Liu, Qingyan Liu, Shuai Mu, Haitao Tao, Xuhui Yang, Yao Li, Qi Xiong, Lijie Wang, Yi Hu

2 registry-linked trialsAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06663098 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Continued PD-L1 Inhibition With Atezolizumab With Rechallenge Chemotherapy in Patients With Sensitive Relapse SCLC Progressing on First-line Platinum-etoposide Chemotherapy and a PD-L1 Inhibitor: CARRY-ON Study-GOIRC-01-2023

TypeinterventionalSponsorGruppo Oncologico Italiano di Ricerca ClinicaRan2025 to 2029Enrolled142ConditionsExtensive Stage Small Cell Lung Cancer (ES-SCLC)ArmsAtezolizumab, Carboplatin, Etoposide
NCT06820762 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Irinotecan Liposome(II) Combined With Ivonescimab as Second-line Treatment for Small Cell Lung Cancer : A Prospective, Single-arm, Multicenter Clinical Study

TypeinterventionalSponsorThe Second Affiliated Hospital of Dalian Medical UniversityRan2025 to 2027Enrolled40ConditionsSCLCArmsirinotecan liposome(II) plus Ivonescimab via intravenously (IV) Q3W for 4-6 cycles, followed by Ivonescimab until disease progression or intolerable toxicity
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Effect of immune checkpoint inhibitors at different treatment time periods on prognosis of patients with extensive-stage small-cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  14. Real-world evaluation of first-line treatment of extensive-stage small-cell lung cancer with atezolizumab plus platinum/etoposide: a focus on patients with brain metastasis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  15. Article
  16. Continuation of immunotherapy beyond progression is beneficial to the survival of advanced non-small-cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lingling LiSchool of Medicine, Nankai University, Tianjin, China.
Tingting LiuSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Qingyan LiuSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Shuai MuSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Haitao TaoSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Xuhui YangSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Yao LiSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Qi XiongSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Lijie WangSenior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Yi HuSchool of Medicine, Nankai University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

immune checkpoint inhibitorPD-1/PD-L1 inhibitorsprognosisrechallenge of immunotherapysmall-cell lung cancer

Identifiers

PMID36147357
PMCPMC9485935

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.